Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 6/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.41 |
| ▸ | KDR | P35968 | 5/20 | 0.40 |
| ▸ | KIT | P10721 | 3/20 | 0.40 |
| ▸ | FLT3 | P36888 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 8/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.38 |
| ▸ | PRKACA | P17612 | 3/20 | 0.38 |
| ▸ | LCK | P06239 | 3/20 | 0.38 |
| ▸ | CSF1R | P07333 | 3/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.38 |
| ▸ | AURKA | O14965 | 2/20 | 0.38 |
| ▸ | CDK2 | P24941 | 2/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.38 |
| ▸ | GSK3B | P49841 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2660353 | 0.81 | PDPK1 (0.47) | PDPK1GAAMAP2K1KDRKIT | |
| SCHEMBL24785172 | 0.81 | PDPK1 (0.39) | PDPK1DYRK1A | |
| SCHEMBL15818216 | 0.78 | KDR (0.45) | PDPK1GAAMAP2K1KDRKIT | |
| SCHEMBL25667724 | 0.78 | GAA (0.58) | PDPK1GAAMAP2K1KDRKIT | |
| SCHEMBL25669174 | 0.75 | PDPK1 (0.42) | PDPK1GAAMAP2K1KDRKIT | |
| SCHEMBL15818095 | 0.74 | PDPK1 (0.41) | PDPK1GAAMAP2K1KDRKIT | |
| SCHEMBL29371666 | 0.73 | PDPK1 (1.00) | PDPK1GAAMAP2K1KDRKIT | |
| SCHEMBL420988 | 0.73 | PDPK1 (1.00) | PDPK1GAAMAP2K1KDRKIT | |
| SCHEMBL21662934 | 0.73 | PDPK1 (0.44) | PDPK1GAAMAP2K1KDRKIT | |
| SCHEMBL16680722 | 0.70 | GAA (0.53) | PDPK1GAAMAP2K1KDRKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230203018-A1 | COVALENT INHIBITORS OF KRAS | ARAXES PHARMA LLC (US) | 2023-06-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230203018-A1 | COVALENT INHIBITORS OF KRAS | KRAS, NRAS, HRAS | PDPK1 1387/4885GAA 3195/4885MAP2K1 250/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.