Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 4/20 | 1.00 |
| ▸ | GAA | P10253 | 2/20 | 0.61 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.56 |
| ▸ | KDR | P35968 | 7/20 | 0.54 |
| ▸ | FLT3 | P36888 | 6/20 | 0.54 |
| ▸ | KIT | P10721 | 6/20 | 0.54 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.51 |
| ▸ | JAK2 | O60674 | 4/20 | 0.51 |
| ▸ | LCK | P06239 | 3/20 | 0.51 |
| ▸ | CSF1R | P07333 | 3/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.51 |
| ▸ | PRKACA | P17612 | 3/20 | 0.51 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.51 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.51 |
| ▸ | PLK4 | O00444 | 2/20 | 0.51 |
| ▸ | AURKA | O14965 | 2/20 | 0.51 |
| ▸ | CDK1 | P06493 | 2/20 | 0.51 |
| ▸ | LYN | P07948 | 2/20 | 0.51 |
| ▸ | SRC | P12931 | 2/20 | 0.51 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29371666 | 1.00 | PDPK1 (1.00) | PDPK1GAAMAP2K1KDRFLT3 | |
| SCHEMBL5209867 | 0.81 | PDPK1 (0.68) | PDPK1GAAMAP2K1KDRFLT3 | |
| SCHEMBL628649 | 0.79 | PDPK1 (0.66) | PDPK1GAAMAP2K1KDRFLT3 | |
| SCHEMBL30065304 | 0.79 | PDPK1 (0.66) | PDPK1GAAMAP2K1KDRFLT3 | |
| SCHEMBL186280 | 0.76 | GAA (1.00) | PDPK1GAAMAP2K1KDRFLT3 | |
| SCHEMBL569660 | 0.76 | GAA (0.61) | PDPK1GAAMAP2K1KDRFLT3 | |
| SCHEMBL10368038 | 0.76 | PDPK1 (0.61) | PDPK1GAAMAP2K1KDRFLT3 | |
| SCHEMBL12928484 | 0.76 | PDPK1 (0.61) | PDPK1GAAMAP2K1KDRFLT3 | |
| SCHEMBL7736987 | 0.76 | PDPK1 (0.61) | PDPK1GAAMAP2K1KDRFLT3 | |
| SCHEMBL760018 | 0.76 | PDPK1 (0.61) | PDPK1GAAMAP2K1KDRFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 131 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111978253-A | (E) -N- (4-iodine-1H-indazole-3-yl) -1-phenyl methylamine compound and preparation method thereof | 浙江工业大学 | 2020-11-24 | — | — | CN | claimed |
| CN-103570754-B | The preparation method of N (4 (base of 3 amino 1H indazoles 4) phenyl) N ' (aminomethyl phenyl of 2 fluorine 5) ureas and its intermediate | 上海创诺医药集团有限公司 | 2018-01-26 | — | — | CN | claimed |
| CN-105924385-A | Diarylthiourea compound with antitumor activity, and preparation method and application thereof | 西安交通大学 | 2016-09-07 | — | — | CN | claimed |
| CN-105906568-A | Cyclopropane diamide compound with antitumor activity and preparation method and application thereof | 西安交通大学 | 2016-08-31 | — | — | CN | claimed |
| CN-103864691-A | Method for preparing compound ABT-869 | UNIV HENAN TCM | 2014-06-18 | — | — | CN | claimed |
| CN-103570754-A | Preparation method of N-(4-(3-amino-1H-indazol-4-yl) phenyl)-N'-(2-fluoro-5-methylphenyl) urea and intermediate thereof | SHANGHAI CHUANGNUO MEDICAL GROUP CO LTD | 2014-02-12 | — | — | CN | claimed |
| CN-102690233-A | Synthetic method of 3-amino-4-iodo-indazole | SHENGSHI TAIKE BIOMEDICAL TECHNOLOGY SUZHOU CO LTD | 2012-09-26 | — | — | CN | claimed |
| CN-101962365-A | Aminoindazole derivatives as protein-kinase inhibitors | AVENTIS PHARMA SA | 2011-02-02 | — | — | CN | claimed |
| US-6949579-B2 | Aminoindazole derivatives and intermediates, preparation thereof, and pharmaceutical compositions thereof | AVENTIS PHARMA S.A. (FR) | 2005-09-27 | — | — | US | claimed |
| CN-1656078-A | Aminoindazole derivatives as protein kinase inhibitors | AVENTIS PHARMA SA (FR) | 2005-08-17 | — | — | CN | claimed |
| US-20040014802-A1 | Aminoindazole derivatives and intermediates, preparation thereof, and pharmaceutical compositions thereof | AVENTIS PHARMA S.A. (FR) | 2004-01-22 | — | — | US | claimed |
| US-20250388577-A1 | METTL3 INHIBITORY COMPOUNDS | STORM THERAPEUTICS LTD (GB) | 2025-12-25 | — | — | US | disclosed |
| US-12358915-B2 | METTL3 inhibitory compounds | STORM Therapeutics Ltd. (GB) | 2025-07-15 | — | — | US | disclosed |
| US-20240383870-A1 | HETEROCYCLIC ALDEHYDE TRAPPING COMPOUNDS AND USES THEREOF | ALDEYRA THERAPEUTICS, INC. | 2024-11-21 | — | — | US | disclosed |
| EP-4362930-A1 | HETEROCYCLIC ALDEHYDE TRAPPING COMPOUNDS AND USES THEREOF | Aldeyra Therapeutics, Inc. (US) | 2024-05-08 | — | — | EP | disclosed |
| WO-2004113304-A1 | INDAZOLE, BENZISOXAZOLE, AND BENZISOTHIAZOLE KINASE INHIBITORS | ABBOTT LABORATORIES (US) | 2004-12-29 | — | — | WO | disclosed |
| EP-1487804-A2 | AMINOINDAZOLE DERIVATIVES AS PROTEIN-KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2004-12-22 | — | — | EP | disclosed |
| US-20040235892-A1 | Indazole and benzisoxazole kinase inhibitors | ABBOTT LABORATORIES | 2004-11-25 | — | — | US | disclosed |
| US-20040014802-A1 | Aminoindazole derivatives and intermediates, preparation thereof, and pharmaceutical compositions thereof | AVENTIS PHARMA S.A. (FR) | 2004-01-22 | — | — | US | disclosed |
| WO-2003078403-A2 | DERIVES D’AMINOINDAZOLES COMME INHIBITEURS DE PROTEINE-KINASE | AVENTIS PHARMA S.A. (FR) | 2003-09-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12358915-B2 | METTL3 inhibitory compounds | METTL3, METTL16, DIMT1 | PDPK1 3854/4885GAA 769/4885MAP2K1 3917/4885 |
| US-20040014802-A1 | Aminoindazole derivatives and intermediates, preparation thereof, and pharmaceutical compositions thereof | CYP2C8, NR0B2, NR2C2 | PDPK1 4495/4885GAA 4778/4885MAP2K1 4200/4885 |
| US-20040235892-A1 | Indazole and benzisoxazole kinase inhibitors | ABL1, MAP3K19, MAP3K1 | PDPK1 67/4885GAA 1778/4885MAP2K1 427/4885 |
| US-20250388577-A1 | METTL3 INHIBITORY COMPOUNDS | METTL3, RNMT, TPMT | PDPK1 4728/4885GAA 2030/4885MAP2K1 4440/4885 |
| US-20240383870-A1 | HETEROCYCLIC ALDEHYDE TRAPPING COMPOUNDS AND USES THEREOF | ALDH1A2, ALDH2, SSB | PDPK1 3263/4885GAA 506/4885MAP2K1 4556/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.