Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MPI | P34949 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | TGM2 | P21980 | 1/20 | 0.37 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | TDP2 | O95551 | 2/20 | 0.36 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 3/20 | 0.35 |
| ▸ | METAP1 | P53582 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3157679 | 0.70 | PDPK1 (0.42) | TGM2PDPK1 | |
| SCHEMBL3147662 | 0.68 | SMN1; SMN2 (0.43) | TSHRALDH1A1MAPTGAAMEN1 | |
| SCHEMBL2567808 | 0.66 | TGM2 (0.38) | MAPTTGM2PDPK1 | |
| SCHEMBL3156405 | 0.66 | PDPK1 (0.44) | TGM2PDPK1 | |
| SCHEMBL3148743 | 0.65 | PIM1 (0.46) | TGM2MEN1KMT2APDPK1 | |
| SCHEMBL3160648 | 0.65 | PDPK1 (0.44) | ALDH1A1MAPTTGM2MEN1KMT2A | |
| SCHEMBL3160654 | 0.65 | PDPK1 (0.44) | ALDH1A1MAPTTGM2MEN1KMT2A | |
| SCHEMBL2572615 | 0.64 | FLT3 (0.42) | TGM2PDPK1 | |
| SCHEMBL3160871 | 0.64 | KMT2A (0.41) | ALDH1A1MAPTL3MBTL1TGM2KMT2A | |
| Isobutane SCHEMBL6119723 | 0.63 | TSHR (0.87) | TSHRALDH1A1MAPTPOLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2384751-A1 | Medicaments for the treatment or prevention of fibrotic diseases | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-11-09 | — | — | EP | disclosed |