Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 7/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 10/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.36 |
| ▸ | FEN1 | P39748 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.35 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25646707 | 0.82 | PIK3CA (0.39) | MTORPIK3CALRRK2PIK3CGPIK3CD | |
| SCHEMBL936915 | 0.74 | PIK3CG (0.49) | PIK3CAPIK3CGPIK3CDPIK3CB | |
| SCHEMBL12909575 | 0.74 | DHFR (0.51) | PIK3CAPIK3CGPIK3CD | |
| SCHEMBL30042556 | 0.73 | CHEK1 (0.39) | PIK3CALRRK2PIK3CGPIK3CD | |
| SCHEMBL25675424 | 0.73 | PIK3CG (0.52) | PIK3CAPIK3CGPIK3CDPIK3CB | |
| SCHEMBL30728843 | 0.73 | CHEK1 (0.50) | — | |
| Hydrochloric Acid SCHEMBL937520 | 0.73 | DHFR (0.50) | PIK3CAPIK3CGPIK3CD | |
| SCHEMBL25271218 | 0.73 | JAK2 (0.40) | PIK3CAPIK3CGPIK3CDPIK3CB | |
| SCHEMBL25271242 | 0.72 | FLT3 (0.47) | — | |
| SCHEMBL25228087 | 0.72 | FLT3 (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230183251-A1 | BICYCLIC AMINES AS CDK12 INHIBITORS | INCYTE CORPORATION | 2023-06-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230183251-A1 | BICYCLIC AMINES AS CDK12 INHIBITORS | CDK12, CDK1, CDK2 | MTOR 349/4885PIK3CA 499/4885LRRK2 526/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.