SCHEMBL2573137

SCHEMBL2573137

CCc1cccc(CC)c1CNC(=O)c1ccc2[nH]nc(-c3cccc(S(N)(=O)=O)c3)c2c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TTK P33981 18/20 1.00
AURKB Q96GD4 3/20 0.62
PLK4 O00444 2/20 0.62
CHEK2 O96017 2/20 0.62
CYP3A4 P08684 2/20 0.62
CYP2C9 P11712 2/20 0.62
INCENP Q9NQS7 1/20 0.56
AURKA O14965 1/20 0.56
CYP1A1 P04798 1/20 0.56
CYP1A2 P05177 1/20 0.56
CYP2E1 P05181 1/20 0.56
CYP2C8 P10632 1/20 0.56
CYP2D6 P10635 1/20 0.56
CYP2A6 P11509 1/20 0.56
CYP4B1 P13584 1/20 0.56
CYP2B6 P20813 1/20 0.56
CYP3A5 P20815 1/20 0.56
CYP2A7 P20853 1/20 0.56
CYP3A7 P24462 1/20 0.56
CYP2F1 P24903 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2567567 0.88 TTK (1.00) TTKAURKBPLK4CHEK2CYP3A4
SCHEMBL12284560 0.87 TTK (0.77) TTKAURKBINCENPMAPK8MAPK1
SCHEMBL12281862 0.87 TTK (0.82) TTKAURKBPLK4CHEK2CYP3A4
SCHEMBL12281666 0.87 TTK (0.82) TTKAURKBPLK4CHEK2CYP3A4
SCHEMBL2571860 0.86 TTK (1.00) TTKAURKBINCENPMAPK1
SCHEMBL12281670 0.83 TTK (1.00) TTKAURKBINCENP
SCHEMBL12282564 0.83 TTK (0.77) TTKAURKBPLK4CHEK2CYP3A4
SCHEMBL12282213 0.82 TTK (0.69) TTKAURKBPLK4CHEK2CYP3A4
SCHEMBL2582534 0.80 TTK (1.00) TTKAURKBINCENP
SCHEMBL2575066 0.80 TTK (0.85) TTKAURKBINCENPCSNK1DMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011123937-A1 KINASE INHIBITORS AND METHOD OF TREATING CANCER WITH SAME UNIVERSITY HEALTH NETWORK (CA) 2011-10-13 WO disclosed