⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12797342 | 1.00 | — | — | |
| SCHEMBL18502866 | 1.00 | — | — | |
| SCHEMBL16854494 | 0.79 | PKM (0.65) | — | |
| SCHEMBL16854481 | 0.79 | PKM (0.65) | — | |
| SCHEMBL12967296 | 0.74 | — | — | |
| SCHEMBL24393373 | 0.74 | PKM (0.39) | — | |
| SCHEMBL6078203 | 0.74 | PKM (0.43) | — | |
| SCHEMBL17778025 | 0.74 | PKM (0.60) | — | |
| SCHEMBL3049543 | 0.74 | PKM (0.43) | — | |
| SCHEMBL29854834 | 0.74 | PKM (0.60) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240124474-A1 | HER2 MUTATION INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2024-04-18 | — | — | US | disclosed |
| US-11834453-B2 | Substituted pyrimido[5,4-d]pyrimidines as HER2 inhibitors | ARRAY BIOPHARMA INC. (US) | 2023-12-05 | — | — | US | disclosed |
| US-20230023851-A1 | HER2 MUTATION INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2023-01-26 | — | — | US | disclosed |
| WO-2022220153-A1 | THIN FILM-FORMING FEEDSTOCK FOR USE IN ATOMIC LAYER DEPOSITION, THIN FILM, METHOD FOR PRODUCING THIN FILM, AND RUTHENIUM COMPOUND | 株式会社ADEKA | 2022-10-20 | — | — | WO | disclosed |
| WO-2022091048-A1 | ECTONUCLEOTIDE PYROPHOSPHATASE-PHOSPHODIESTERASE-1 (ENPP1) INHIBITORS AND USES THEREOF | INTEGRAL BIOSCIENCES PRIVATE LIMITED (IN) | 2022-05-05 | — | — | WO | disclosed |
| WO-2022003575-A1 | HER2 MUTATION INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2022-01-06 | — | — | WO | disclosed |
| US-10329263-B2 | Disubstituted 1, 2, 4-triazine compound | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2019-06-25 | — | — | US | disclosed |
| US-10029993-B2 | Disubstituted 1, 2, 4-triazine compound | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2018-07-24 | — | — | US | disclosed |
| US-10029993-B2 | Disubstituted 1, 2, 4-triazine compound | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2018-07-24 | — | — | US | disclosed |
| US-9790221-B2 | Heteroaryl compounds as IRAK inhibitors and uses thereof | MERCK PATENT GMBH (DE) | 2017-10-17 | — | — | US | disclosed |
| EP-2745837-A1 | Glomerulonephritis Treatment | Avexxin AS (NO) | 2014-06-25 | — | — | EP | disclosed |
| US-20130245127-A1 | RHEUMATOID ARTHRITIS TREATMENT | AVEXXIN AS (NO) | 2013-09-19 | — | — | US | disclosed |
| US-20120157425-A1 | NEW COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2012-06-21 | — | — | US | disclosed |
| US-20120136066-A1 | Glomerulonephritis Treatment | AVEXXIN AS (NO) | 2012-05-31 | — | — | US | disclosed |
| WO-2012028688-A1 | RHEUMATOID ARTHRITIS TREATMENT USING POLYUNSATURATED LONG CHAIN KETONES | AVEXXIN AS (NO) | 2012-03-08 | — | — | WO | disclosed |
| US-20100311843-A1 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF GLOMERULONEPHRITIS | AVEXXIN AS (NO) | 2010-12-09 | — | — | US | disclosed |
| EP-1487784-A4 | NOVEL TRIFLUOROMETHYLEPINEPHRINE COMPOUNDS AND METHODS OF MAKING AND USING THEREOF | US ARMY MED RES MAT COMMAND (US) | 2005-03-30 | — | — | EP | disclosed |
| EP-1487784-A2 | NOVEL TRIFLUOROMETHYLEPINEPHRINE COMPOUNDS AND METHODS OF MAKING AND USING THEREOF | U.S. Army Medical Research and Materiel Command (US) | 2004-12-22 | — | — | EP | disclosed |
| WO-2003103609-A2 | NOVEL TRIFLUOROMETHYLEPINEPHRINE COMPOUNDS AND METHODS OF MAKING AND USING THEREOF | U.S. ARMY MEDICAL RESEARCH AND MATERIEL COMMAND (US) | 2003-12-18 | — | — | WO | disclosed |
| US-6350892-B1 | ENZYME INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY | 2002-02-26 | — | — | US | disclosed |