Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 19/20 | 0.47 |
| ▸ | JAK1 | P23458 | 4/20 | 0.46 |
| ▸ | JAK2 | O60674 | 2/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31369051 | 1.00 | TYK2 (0.47) | TYK2JAK1JAK2KCNH2 | |
| SCHEMBL25670345 | 0.84 | TYK2 (0.52) | TYK2JAK1JAK2KCNH2 | |
| SCHEMBL25748683 | 0.84 | TYK2 (0.52) | TYK2JAK1JAK2KCNH2 | |
| SCHEMBL31369032 | 0.84 | TYK2 (0.52) | TYK2JAK1JAK2KCNH2 | |
| SCHEMBL28662538 | 0.84 | TYK2 (0.52) | TYK2JAK1JAK2KCNH2 | |
| SCHEMBL30465864 | 0.84 | TYK2 (0.52) | TYK2JAK1JAK2KCNH2 | |
| SCHEMBL29882968 | 0.83 | TYK2 (0.61) | TYK2JAK1JAK2KCNH2 | |
| SCHEMBL25750974 | 0.83 | TYK2 (0.61) | TYK2JAK1JAK2KCNH2 | |
| SCHEMBL31369033 | 0.82 | TYK2 (0.48) | TYK2JAK1JAK2KCNH2 | |
| SCHEMBL28647134 | 0.82 | TYK2 (0.48) | TYK2JAK1JAK2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023108536-A1 | TYK2 INHIBITORS AND COMPOSITIONS AND METHODS THEREOF | LYNK PHARMACEUTICALS CO. LTD. (CN) | 2023-06-22 | — | — | WO | disclosed |
| CN-113563309-A | Pyridine derivative and preparation method and application thereof | 浙江海正药业股份有限公司 | 2021-10-29 | — | — | CN | disclosed |