Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 14/20 | 0.40 |
| ▸ | AKT1 | P31749 | 1/20 | 0.38 |
| ▸ | AKT2 | P31751 | 1/20 | 0.38 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.36 |
| ▸ | PRKDC | P78527 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | LIPE | Q05469 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25679238 | 0.85 | PIK3CA (0.50) | PIK3CAAKT1AKT2AKT3PIK3CB | |
| SCHEMBL25222115 | 0.82 | PIK3CA (0.64) | PIK3CAAKT1AKT2AKT3PIK3CB | |
| SCHEMBL31035685 | 0.81 | PIK3CA (0.36) | PIK3CAAKT1AKT2AKT3PIK3CB | |
| SCHEMBL31035499 | 0.81 | PIK3CA (0.38) | PIK3CAAKT1AKT2AKT3PIK3CB | |
| SCHEMBL30889677 | 0.81 | PIK3CA (0.38) | PIK3CAAKT1AKT2AKT3PIK3CB | |
| SCHEMBL25679260 | 0.79 | PIK3CA (0.40) | PIK3CAAKT1AKT2AKT3PIK3CB | |
| SCHEMBL31516556 | 0.77 | PIK3CA (0.53) | PIK3CAAKT1AKT2AKT3 | |
| SCHEMBL30373211 | 0.75 | PIK3CA (0.41) | PIK3CAAKT1AKT2AKT3PIK3CB | |
| SCHEMBL25185327 | 0.75 | PIK3CA (0.43) | PIK3CAAKT1AKT2AKT3PIK3CB | |
| SCHEMBL25184861 | 0.75 | PIK3CA (0.41) | PIK3CAAKT1AKT2AKT3PIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023104111-A1 | FUSED HETEROCYCLIC COMPOUNDS AS PI3KALPHA INHIBITORS | NANJING ZENSHINE PHARMACEUTICALS CO., LTD. (CN) | 2023-06-15 | — | — | WO | disclosed |