Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | ACACB | O00763 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | RXRA | P19793 | 7/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 7/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 7/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | PLAU | P00749 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18611257 | 0.94 | TSHR (0.36) | TSHRACACBCYP1A2CYP3A4ALDH1A1 | |
| SCHEMBL16416281 | 0.80 | EDNRA (0.38) | TSHRACACB | |
| SCHEMBL20334287 | 0.80 | KDM4E (0.37) | TSHRACACBALDH1A1TLR7LMNA | |
| SCHEMBL15677660 | 0.79 | RXRA (0.37) | ACACBALDH1A1RXRAGRIN1GRIN2B | |
| SCHEMBL19732845 | 0.77 | SYK (0.39) | RXRAGRIN1GRIN2B | |
| Ammonia Solution, Strong SCHEMBL18985316 | 0.77 | RXRA (0.36) | ACACBALDH1A1RXRAGRIN1GRIN2B | |
| SCHEMBL15427262 | 0.77 | CYP2D6 (0.39) | ACACBCYP1A2CYP3A4RXRAGRIN1 | |
| SCHEMBL26152964 | 0.77 | ACACB (0.35) | TSHRACACBALDH1A1GRIN1GRIN2B | |
| SCHEMBL6423669 | 0.76 | TSHR (0.41) | TSHRACACBTLR7NUDT1 | |
| SCHEMBL18578353 | 0.75 | EDNRA (0.38) | ACACBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024137329-A1 | METHODS FOR THE SYNTHESIS OF COMPLEMENT FACTOR D INHIBITORS AND INTERMEDIATES THEREOF | ALEXION PHARMACEUTICALS, INC. (US) | 2024-06-27 | — | — | WO | disclosed |
| WO-2023114198-A2 | METHODS FOR THE SYNTHESIS OF COMPLEMENT FACTOR D INHIBITORS | ALEXION PHARMACEUTICALS, INC. (US) | 2023-06-22 | — | — | WO | disclosed |
| WO-2023114200-A2 | METHODS FOR THE SYNTHESIS OF COMPLEMENT FACTOR D INHIBITORS AND INTERMEDIATES THEREOF | ALEXION PHARMACEUTICALS, INC. (US) | 2023-06-22 | — | — | WO | disclosed |