Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 2/20 | 0.57 |
| ▸ | NTRK1 | P04629 | 5/20 | 0.42 |
| ▸ | PIM1 | P11309 | 5/20 | 0.42 |
| ▸ | ACVR1 | Q04771 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18578663 | 0.83 | PIK3CG (0.54) | PIK3CGNTRK1PIM1ACVR1KDM4E | |
| SCHEMBL16646633 | 0.76 | MAPT (0.44) | ALDH1A1MAPTHSD17B10SMN1; SMN2NPC1 | |
| SCHEMBL7465828 | 0.73 | SMN1; SMN2 (0.41) | KDM4EALDH1A1MAPTHSD17B10SMN1; SMN2 | |
| SCHEMBL10556141 | 0.72 | PIK3CG (1.00) | PIK3CGNTRK1PIM1ACVR1KDM4E | |
| Hydrochloric Acid SCHEMBL7826142 | 0.71 | MAPT (0.41) | KDM4EALDH1A1MAPTHSD17B10SMN1; SMN2 | |
| SCHEMBL16643961 | 0.70 | MAPT (0.40) | ALDH1A1MAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL9728946 | 0.70 | CDK2 (0.53) | KDM4EALDH1A1HSD17B10HPGDKMT2A | |
| SCHEMBL29791702 | 0.69 | KDM4E (0.45) | PIK3CGKDM4EALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL18717553 | 0.68 | PDE2A (0.43) | KDM4EALDH1A1MAPTSMN1; SMN2NPC1 | |
| SCHEMBL30320017 | 0.67 | RAB9A (0.54) | PIK3CGKDM4EALDH1A1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024137329-A1 | METHODS FOR THE SYNTHESIS OF COMPLEMENT FACTOR D INHIBITORS AND INTERMEDIATES THEREOF | ALEXION PHARMACEUTICALS, INC. (US) | 2024-06-27 | — | — | WO | disclosed |
| WO-2023114200-A2 | METHODS FOR THE SYNTHESIS OF COMPLEMENT FACTOR D INHIBITORS AND INTERMEDIATES THEREOF | ALEXION PHARMACEUTICALS, INC. (US) | 2023-06-22 | — | — | WO | disclosed |
| WO-2023114198-A2 | METHODS FOR THE SYNTHESIS OF COMPLEMENT FACTOR D INHIBITORS | ALEXION PHARMACEUTICALS, INC. (US) | 2023-06-22 | — | — | WO | disclosed |