Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.46 |
| ▸ | TERT | O14746 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 6/20 | 0.41 |
| ▸ | MEN1 | O00255 | 6/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 5/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | APAF1 | O14727 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25680949 | 0.84 | SMN1; SMN2 (0.46) | SMN1; SMN2ATAD2TERTKDM4EALDH1A1 | |
| SCHEMBL23679807 | 0.75 | SMN1; SMN2 (0.55) | SMN1; SMN2KDM4EALDH1A1HPGDGLA | |
| SCHEMBL6232931 | 0.73 | SMN1; SMN2 (0.58) | SMN1; SMN2KDM4EALDH1A1HPGDNPC1 | |
| SCHEMBL6230772 | 0.73 | SMN1; SMN2 (0.58) | SMN1; SMN2KDM4EALDH1A1HPGDNPC1 | |
| SCHEMBL25682666 | 0.72 | SMN1; SMN2 (0.44) | SMN1; SMN2KDM4EALDH1A1HPGDGLA | |
| SCHEMBL30533973 | 0.72 | GAA (0.41) | SMN1; SMN2KDM4EALDH1A1HPGDGLA | |
| SCHEMBL25261573 | 0.72 | GAA (0.41) | SMN1; SMN2KDM4EALDH1A1HPGDGLA | |
| SCHEMBL9980836 | 0.72 | ALOX15 (0.58) | SMN1; SMN2KDM4EALDH1A1HPGDGLA | |
| SCHEMBL6200788 | 0.69 | KDM4E (0.58) | SMN1; SMN2ATAD2TERTKDM4EALDH1A1 | |
| SCHEMBL25220378 | 0.69 | SMN1; SMN2 (0.58) | SMN1; SMN2ALDH1A1HPGDNPC1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230203010-A1 | BICYCLIC AMINE CDK12 INHIBITORS | INCYTE CORPORATION | 2023-06-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230203010-A1 | BICYCLIC AMINE CDK12 INHIBITORS | CDK12, CDK1, CDK2 | SMN1; SMN2 2951/4885ATAD2 728/4885TERT 1321/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.