SCHEMBL25690358

SCHEMBL25690358

CC(C)(CC(=O)O)NC(=O)c1ncc(C2CCCCCCCCCCC2)cc1O

nearest known ligand 0.46

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
EGLN1 Q9GZT9 19/20 0.46
EGLN2 Q96KS0 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25690401 0.80 EGLN1 (0.48) EGLN1
SCHEMBL25690381 0.80 EGLN1 (0.48) EGLN1
SCHEMBL23308729 0.76 KDM4E (0.54) EGLN1
SCHEMBL22326606 0.76 KDM4E (0.54) EGLN1
SCHEMBL30457318 0.69 EGLN1 (0.67) EGLN1EGLN2
SCHEMBL25227579 0.69 EGLN1 (0.67) EGLN1EGLN2
SCHEMBL10586417 0.65 KDM4E (0.54)
SCHEMBL30472839 0.64 OPRK1 (0.43)
SCHEMBL14319655 0.61 EGLN1 (0.61) EGLN1
SCHEMBL7095023 0.61 CYP3A4 (0.49)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023111990-A1 SELECTIVE PHD1 INHIBITOR COMPOUNDS, COMPOSITIONS, AND METHODS OF USE AKEBIA THERAPEUTICS, INC. (US) 2023-06-22 WO disclosed