SCHEMBL25692276

SCHEMBL25692276

O=C(Nc1cccc(N2CCOCC2)n1)c1ccc(Br)cc1N1CCC2(CC1)CC2

nearest known ligand 0.76

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
▸ KIF18A Q8NI77 20/20 0.76

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25692263 0.90 KIF18A (0.77) KIF18A
SCHEMBL24318989 0.89 KIF18A (0.70) KIF18A
SCHEMBL29609024 0.89 KIF18A (0.70) KIF18A
SCHEMBL22153001 0.87 KIF18A (0.74) KIF18A
SCHEMBL22152319 0.87 KIF18A (0.74) KIF18A
SCHEMBL31718060 0.87 KIF18A (0.74) KIF18A
SCHEMBL22122461 0.87 KIF18A (0.79) KIF18A
SCHEMBL22152320 0.87 KIF18A (0.79) KIF18A
SCHEMBL29608181 0.87 KIF18A (0.79) KIF18A
SCHEMBL22122462 0.87 KIF18A (0.79) KIF18A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3897855-B1 KIF18A INHIBITORS AMGEN INC (US) 2023-06-07 — — EP disclosed
Send feedback