Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 2/20 | 0.47 |
| ▸ | CHRNA5 | P30532 | 2/20 | 0.47 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.47 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.47 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.41 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.38 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25694061 | 1.00 | CHRNB2 (0.47) | CHRNB2CHRNA5CHRNA7CHRNA4ABCB1 | |
| SCHEMBL25235927 | 0.85 | CHRNB2 (0.53) | CHRNB2CHRNA5CHRNA7CHRNA4CES2 | |
| SCHEMBL25694144 | 0.81 | CHRNB2 (0.46) | CHRNB2CHRNA5CHRNA7CHRNA4CES2 | |
| SCHEMBL31603568 | 0.80 | CHRNB2 (0.48) | CHRNB2CHRNA5CHRNA7CHRNA4ABCB1 | |
| SCHEMBL30223760 | 0.79 | CHRNB2 (0.47) | CHRNB2CHRNA5CHRNA7CHRNA4ABCB1 | |
| SCHEMBL31603370 | 0.79 | CHRNB2 (0.47) | CHRNB2CHRNA5CHRNA7CHRNA4ABCB1 | |
| SCHEMBL25694133 | 0.79 | CHRNB2 (0.47) | CHRNB2CHRNA5CHRNA7CHRNA4ABCB1 | |
| SCHEMBL2433304 | 0.76 | CHRNB2 (0.47) | CHRNB2CHRNA5CHRNA7CHRNA4ABCB1 | |
| SCHEMBL31603475 | 0.76 | CHRNB2 (0.45) | CHRNB2CHRNA5CHRNA7CHRNA4ABCB1 | |
| SCHEMBL5155694 | 0.76 | CHRNB2 (0.47) | CHRNB2CHRNA5CHRNA7CHRNA4ABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023114200-A2 | METHODS FOR THE SYNTHESIS OF COMPLEMENT FACTOR D INHIBITORS AND INTERMEDIATES THEREOF | ALEXION PHARMACEUTICALS, INC. (US) | 2023-06-22 | — | — | WO | disclosed |