Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB5 | P28074 | 6/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.33 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL105904 | 0.88 | TSHR (0.38) | PSMB5ALDH1A1RNPEPSLC7A5TSHR | |
| SCHEMBL1782638 | 0.76 | ALDH1A1 (0.40) | PSMB5ALDH1A1RNPEPSLC7A5MEN1 | |
| SCHEMBL28090514 | 0.74 | TSHR (0.35) | TSHR | |
| SCHEMBL15782448 | 0.72 | TSHR (0.39) | ALDH1A1RNPEPSLC7A5TSHRLMNA | |
| SCHEMBL706865 | 0.72 | TSHR (0.39) | ALDH1A1RNPEPSLC7A5TSHRLMNA | |
| SCHEMBL16203065 | 0.72 | TSHR (0.39) | ALDH1A1RNPEPSLC7A5TSHRLMNA | |
| SCHEMBL14084266 | 0.72 | TSHR (0.39) | ALDH1A1RNPEPSLC7A5TSHRLMNA | |
| SCHEMBL1296613 | 0.71 | CA1 (0.37) | ALDH1A1TSHR | |
| SCHEMBL12570564 | 0.70 | RNPEP (0.39) | PSMB5ALDH1A1RNPEPSLC7A5 | |
| SCHEMBL107969 | 0.70 | PSMB5 (0.40) | PSMB5RNPEPSLC7A5TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230183216-A1 | PYRIDIZIN-3(2H)-ONE DERIVATIVES | GILEAD SCIENCES, INC. | 2023-06-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230183216-A1 | PYRIDIZIN-3(2H)-ONE DERIVATIVES | PIR, CYP3A43, CYP1A2 | PSMB5 4216/4885ALDH1A1 401/4885RNPEP 3348/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.