Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 6/20 | 0.57 |
| ▸ | ATXN2 | Q99700 | 6/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.43 |
| ▸ | TSHR | P16473 | 5/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23704607 | 0.82 | SMN1; SMN2 (0.55) | ENPP2ATXN2SMN1; SMN2NPC1RAB9A | |
| SCHEMBL6972358 | 0.81 | SMN1; SMN2 (0.65) | ENPP2SMN1; SMN2NPC1RAB9ACYP2C19 | |
| SCHEMBL30553394 | 0.81 | SMN1; SMN2 (0.64) | ENPP2ATXN2SMN1; SMN2NPC1RAB9A | |
| SCHEMBL16616151 | 0.81 | SMN1; SMN2 (0.54) | ENPP2ATXN2SMN1; SMN2NPC1RAB9A | |
| SCHEMBL27172319 | 0.81 | ENPP2 (0.57) | ENPP2ATXN2SMN1; SMN2NPC1RAB9A | |
| SCHEMBL27194552 | 0.81 | ENPP2 (0.49) | ENPP2ATXN2SMN1; SMN2NPC1RAB9A | |
| Iodide SCHEMBL30143510 | 0.80 | ENPP2 (0.53) | ENPP2ATXN2SMN1; SMN2NPC1RAB9A | |
| SCHEMBL9963117 | 0.80 | MEN1 (0.50) | ENPP2ATXN2SMN1; SMN2NPC1RAB9A | |
| SCHEMBL26204656 | 0.80 | MEN1 (0.50) | ENPP2ATXN2SMN1; SMN2NPC1RAB9A | |
| SCHEMBL2241312 | 0.79 | SMN1; SMN2 (0.59) | ENPP2SMN1; SMN2NPC1RAB9ACYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230183216-A1 | PYRIDIZIN-3(2H)-ONE DERIVATIVES | GILEAD SCIENCES, INC. | 2023-06-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230183216-A1 | PYRIDIZIN-3(2H)-ONE DERIVATIVES | PIR, CYP3A43, CYP1A2 | ENPP2 4196/4885ATXN2 1433/4885SMN1; SMN2 2003/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.