Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 1/20 | 0.41 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.39 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.37 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.35 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.35 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.34 |
| ▸ | F10 | P00742 | 1/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29998665 | 1.00 | PDE2A (0.41) | PDE2APIK3R1PIK3CAPDE1BLRRK2 | |
| SCHEMBL23459396 | 1.00 | PDE2A (0.41) | PDE2APIK3R1PIK3CAPDE1BLRRK2 | |
| SCHEMBL29997804 | 0.88 | PDE1B (0.45) | PDE2APDE1BLRRK2NPC1RAB9A | |
| SCHEMBL23459340 | 0.88 | PDE1B (0.45) | PDE2APDE1BLRRK2NPC1RAB9A | |
| SCHEMBL29997749 | 0.81 | MAPT (0.51) | PDE2ARAB9AAPP | |
| SCHEMBL17819740 | 0.81 | MAPT (0.51) | PDE2ARAB9AAPP | |
| SCHEMBL23477951 | 0.81 | PDE2A (0.36) | PDE2APIK3R1PIK3CAPDE1BSPHK2 | |
| SCHEMBL23477942 | 0.81 | DRD4 (0.40) | PDE2APDE1BLRRK2GPR84 | |
| SCHEMBL23477789 | 0.78 | PIK3R1 (0.41) | PDE2APIK3R1PIK3CAPDE1BLRRK2 | |
| SCHEMBL29997858 | 0.78 | PIK3R1 (0.41) | PDE2APIK3R1PIK3CAPDE1BLRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11685734-B2 | ATM kinase inhibitors and compositions and methods of use thereof | CHDI FOUNDATION, INC. (US) | 2023-06-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11685734-B2 | ATM kinase inhibitors and compositions and methods of use thereof | ATM, CHEK2, CHEK1 | PDE2A 1236/4885PIK3R1 470/4885PIK3CA 148/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.