Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE1B | Q01064 | 5/20 | 0.45 |
| ▸ | PDE2A | O00408 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.37 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.37 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23459340 | 1.00 | PDE1B (0.45) | PDE1BPDE2ATSHRNPSR1KMT2A | |
| SCHEMBL25698372 | 0.88 | PDE2A (0.41) | PDE1BPDE2ANPC1RAB9ALRRK2 | |
| SCHEMBL29998665 | 0.88 | PDE2A (0.41) | PDE1BPDE2ANPC1RAB9ALRRK2 | |
| SCHEMBL23459396 | 0.88 | PDE2A (0.41) | PDE1BPDE2ANPC1RAB9ALRRK2 | |
| SCHEMBL23477942 | 0.88 | DRD4 (0.40) | PDE1BPDE2AL3MBTL1HPGDMAPT | |
| SCHEMBL29997749 | 0.82 | MAPT (0.51) | PDE2ANPSR1ALDH1A1L3MBTL1RAB9A | |
| SCHEMBL17819740 | 0.82 | MAPT (0.51) | PDE2ANPSR1ALDH1A1L3MBTL1RAB9A | |
| SCHEMBL23477951 | 0.80 | PDE2A (0.36) | PDE1BPDE2ANPC1RAB9A | |
| SCHEMBL23459240 | 0.78 | DRD4 (0.37) | PDE2AL3MBTL1MAPTGRM2 | |
| SCHEMBL29997788 | 0.78 | DRD4 (0.37) | PDE2AL3MBTL1MAPTGRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4069366-A1 | ATM KINASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF | CHDI Foundation, Inc. (US) | 2022-10-12 | — | — | EP | disclosed |