Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 6/20 | 0.39 |
| ▸ | MTOR | P42345 | 8/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 9/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.36 |
| ▸ | ATRIP | Q8WXE1 | 5/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.35 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.35 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24024152 | 0.78 | ATR (0.40) | ATRMTORPIK3CAPIK3CDATRIP | |
| SCHEMBL24024138 | 0.76 | ATR (0.41) | ATRMTORPIK3CAPIK3CDATRIP | |
| SCHEMBL19195025 | 0.72 | ATR (0.63) | ATRATRIP | |
| SCHEMBL25700433 | 0.68 | ATR (0.48) | ATRMTORATRIP | |
| SCHEMBL24024154 | 0.67 | ATR (0.45) | ATRMTORPIK3CAPIK3CDATRIP | |
| SCHEMBL23629220 | 0.67 | ATR (0.47) | ATRMTORATRIP | |
| SCHEMBL23629225 | 0.67 | ATR (0.45) | ATRMTORATRIPCHEK1PDCD1 | |
| SCHEMBL24024155 | 0.66 | ATR (0.40) | ATRMTORPIK3CAPIK3CDATRIP | |
| SCHEMBL24174467 | 0.65 | MTOR (0.48) | ATRMTORPIK3CAPIK3CDATRIP | |
| SCHEMBL24174454 | 0.65 | MTOR (0.48) | ATRMTORPIK3CAPIK3CDATRIP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3846904-B1 | 5-MORPHOLIN-4-YL-PYRAZOLO[4,3-B]PYRIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2023-05-31 | — | — | EP | disclosed |