Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.32 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.32 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.32 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.32 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.32 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.32 |
| ▸ | F10 | P00742 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 5/20 | 0.32 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | DRD3 | P35462 | 1/20 | 0.31 |
| ▸ | HTR6 | P50406 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2568026 | 0.93 | PSEN1 (0.33) | NPC1RAB9AHDAC1HDAC2PSEN1 | |
| SCHEMBL3032956 | 0.88 | F10 (0.43) | NPC1RAB9AF10KDM4EAR | |
| SCHEMBL2571305 | 0.87 | KDM4E (0.36) | NPC1RAB9AHDAC1HDAC2PSEN1 | |
| SCHEMBL2566978 | 0.87 | HRH3 (0.37) | NPC1RAB9APSEN1PSEN2APH1B | |
| SCHEMBL2568969 | 0.85 | RAB9A (0.36) | NPC1RAB9AHDAC1HDAC2PSEN1 | |
| SCHEMBL2571214 | 0.84 | KDM4E (0.40) | NPC1RAB9AHDAC1HDAC2PSEN1 | |
| SCHEMBL2568110 | 0.83 | HDAC1 (0.34) | NPC1RAB9AHDAC1HDAC2PSEN1 | |
| SCHEMBL2571863 | 0.82 | RAB9A (0.34) | NPC1RAB9AHDAC1HDAC2PSEN1 | |
| SCHEMBL2567154 | 0.82 | AR (0.33) | NPC1RAB9AHDAC1HDAC2PSEN1 | |
| SCHEMBL3017690 | 0.81 | F10 (0.42) | NPC1RAB9APSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899330-B9 | SUBSTITUTED GLYCINAMIDES HAVING AN ANTITHROMBOTIC AND FACTOR XA-INHIBITING EFFECT | BOEHRINGER INGELHEIM INT (DE) | 2011-11-09 | — | — | EP | disclosed |
| EP-1899330-B1 | SUBSTITUTED GLYCINAMIDES HAVING AN ANTITHROMBOTIC AND FACTOR XA-INHIBITING EFFECT | BOEHRINGER INGELHEIM INT (DE) | 2010-11-24 | — | — | EP | disclosed |