Piperocaine

Piperocaine

SCHEMBL25714

C[C@@H]1CCCCN1CCCOC(=O)c1ccccc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
SCN1A P35498 2/20 1.00
SCN2A Q99250 2/20 1.00
SCN3A Q9NY46 2/20 1.00
CHRNB2 P17787 1/20 0.53
CHRNA5 P30532 1/20 0.53
CHRNA7 P36544 1/20 0.53
CHRNA4 P43681 1/20 0.53
HRH3 Q9Y5N1 9/20 0.53
TDP1 Q9NUW8 1/20 0.51
BCHE P06276 2/20 0.48
LMNA P02545 1/20 0.48
CYP2D6 P10635 1/20 0.48
ALDH1A1 P00352 1/20 0.47
MAPT P10636 1/20 0.47
MAOB P27338 1/20 0.47
HRH2 P25021 1/20 0.47
HRH1 P35367 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Piperocaine SCHEMBL25713 1.00 SCN1A (1.00) SCN1ASCN2ASCN3ACHRNB2CHRNA5
Piperocaine SCHEMBL503030 0.99 SCN1A (0.98) SCN1ASCN2ASCN3ACHRNB2CHRNA5
Piperocaine SCHEMBL503032 0.99 SCN1A (0.98) SCN1ASCN2ASCN3ACHRNB2CHRNA5
Piperocaine SCHEMBL9224615 0.98 SCN1A (0.95) SCN1ASCN2ASCN3ACHRNB2CHRNA5
Piperocaine SCHEMBL9224611 0.98 SCN1A (0.95) SCN1ASCN2ASCN3ACHRNB2CHRNA5
Piperocaine SCHEMBL7615890 0.95 SCN1A (0.91) SCN1ASCN2ASCN3ACHRNB2CHRNA5
Biphenyl SCHEMBL23174836 0.84 SCN1A (0.72) SCN1ASCN2ASCN3AHRH3HRH2
Cyclomethycaine SCHEMBL25346 0.84 SCN1A (1.00) SCN1ASCN2ASCN3AHRH3CYP2D6
Cyclomethycaine SCHEMBL25345 0.84 SCN1A (1.00) SCN1ASCN2ASCN3AHRH3CYP2D6
Cyclomethycaine SCHEMBL634211 0.83 SCN1A (0.98) SCN1ASCN2ASCN3AHRH3CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 5075 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260144801-A1 COMPOSITIONS AND METHODS FOR PREVENTING OR TREATING MUSCLE CONDITIONS THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) 2026-05-28 US claimed
US-20260137637-A1 ANESTHETIC AGENT MICRO AND NANO PARTICLES, AND METHODS OF MAKING AND USING THE SAME HAAS ERIC (US) 2026-05-21 US claimed
US-12622873-B2 Composition of matter comprising liposomes embedded in a polymeric matrix and methods of using same YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. (IL) 2026-05-12 US claimed
EP-4735042-A1 MERCERIZED DECELLULARIZED PARTICLES FOR SLOW RELEASE APPLICATIONS AND METHODS THEREOF Spiderwort Biotechnologies Inc. (CA) 2026-05-06 EP claimed
US-20260115156-A1 INJECTABLE COMPOSITION INCLUDING HYDROGEL CONTAINING ANESTHETIC AGENT UNIV KOREA RES & BUS FOUND (KR) 2026-04-30 US claimed
EP-3723819-B1 WOUND DRESSING ANIMAL ETHICS PTY LTD (AU) 2026-04-22 EP claimed
US-20260083666-A1 METHOD OF TREATING DISEASE CREWS THOMAS M (US) 2026-03-26 US claimed
EP-4436552-B1 GASTRO-RETENTIVE ORAL DOSAGE UNIT CONTAINING A LOCAL ANAESTHETIC OREXA B V (NL) 2026-02-04 EP claimed
US-12527756-B2 Anesthetic agent micro and nano particles, and methods of making and using the same HAAS ERIC (US) 2026-01-20 US claimed
WO-2025235864-A1 COATED NEEDLE ADMINISTRATION SYSTEMS EVOLUS, INC. (US) 2025-11-13 WO claimed
WO-1994017790-A1 USE OF TOPICAL ANESTHETICS FOR THE MANUFACTURE OF A MEDICAMENT FOR THE TREATMENT OF BRONCHIAL ASTHMA MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) 1994-08-18 WO claimed
EP-0336901-B1 Anesthetic skin moisturizing composition and method of preparing same WARNER LAMBERT CO (US) 1994-03-30 EP claimed
EP-0471135-A2 Compositions, medicaments and methods for the promotion of hair growth Hallam, Kenneth M. (US) 1992-02-19 EP claimed
EP-0126684-B1 DRUG DELIVERY SYSTEM UTILIZING THERMOSETTING GELS MERCK & CO. INC. (US) 1991-08-28 EP claimed
US-5002974-A Oil phase with nonionic surfactant, water phase with thickener for emulsions for skin WARNER-LAMBERT CO. (US) 1991-03-26 US claimed
EP-0126684-A2 Drug delivery system utilizing thermosetting gels MERCK & CO. INC. (US) 1984-11-28 EP claimed
US-4474751-A SUSTAINED RELEASE USING AN ALKYLENEDIAMINE-MODIFIED ETHYLENE OXIDE-PROPYLENE OXIDE COPOLYMER MERCK & CO., INC. (US) 1984-10-02 US claimed
US-4186185-A Compositions comprising arylene substituted poly(orthoesters) containing useful agents ALZA CORPORATION (US) 1980-01-29 US claimed
US-4066747-A Polymeric orthoesters housing beneficial drug for controlled release therefrom ALZA CORPORATION (US) 1978-01-03 US claimed
US-4041174-A INJECTING AN ESTER LOCAL ANESTHETIC ROM-AMER PHARMACEUTICALS, LTD. (US) 1977-08-09 US claimed