Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 5/20 | 0.40 |
| ▸ | TNK2 | Q07912 | 12/20 | 0.37 |
| ▸ | PLK4 | O00444 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | PAK4 | O96013 | 1/20 | 0.37 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.37 |
| ▸ | INSR | P06213 | 1/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | FYN | P06241 | 1/20 | 0.37 |
| ▸ | CSF1R | P07333 | 1/20 | 0.37 |
| ▸ | LYN | P07948 | 1/20 | 0.37 |
| ▸ | IGF1R | P08069 | 1/20 | 0.37 |
| ▸ | MET | P08581 | 1/20 | 0.37 |
| ▸ | KIT | P10721 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25714868 | 0.88 | KDR (0.39) | MAP4K4TNK2PLK4AURKADAPK3 | |
| SCHEMBL25715609 | 0.84 | TNK2 (0.37) | TNK2PLK4AURKADAPK3ROCK2 | |
| SCHEMBL25715652 | 0.82 | FGFR1 (0.35) | MAP4K4TNK2PLK4AURKADAPK3 | |
| SCHEMBL25715554 | 0.79 | SRC (0.42) | MAP4K4TNK2ABL1LCKSRC | |
| SCHEMBL25714866 | 0.79 | TNK2 (0.41) | MAP4K4TNK2 | |
| SCHEMBL25714869 | 0.78 | KDR (0.47) | PLK4AURKADAPK3ROCK2PAK4 | |
| SCHEMBL25716910 | 0.78 | KDR (0.46) | TNK2PLK4AURKADAPK3ROCK2 | |
| SCHEMBL25715417 | 0.77 | KDR (0.37) | TNK2PLK4AURKADAPK3ROCK2 | |
| SCHEMBL22676841 | 0.72 | KDR (0.50) | TNK2PLK4AURKADAPK3ROCK2 | |
| SCHEMBL30303333 | 0.72 | KDR (0.50) | TNK2PLK4AURKADAPK3ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023104035-A1 | SUBSTITUTED MONOCYCLIC OR BICYCLIC HETEROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | 英矽智能科技(上海)有限公司 | 2023-06-15 | — | — | WO | disclosed |