Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.43 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.39 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.39 |
| ▸ | CCNC | P24863 | 1/20 | 0.38 |
| ▸ | CDK8 | P49336 | 1/20 | 0.38 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.38 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.38 |
| ▸ | F10 | P00742 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.37 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.37 |
| ▸ | INSR | P06213 | 1/20 | 0.37 |
| ▸ | ITK | Q08881 | 1/20 | 0.37 |
| ▸ | WDR5 | P61964 | 3/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.36 |
| ▸ | BCL3 | P20749 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL165026 | 0.90 | LRRK2 (0.46) | LRRK2PDCD1CD274CCNCCDK8 | |
| SCHEMBL168274 | 0.85 | CCR5 (0.40) | LRRK2PDCD1CD274F10ENPP2 | |
| SCHEMBL167703 | 0.81 | GSK3B (0.42) | LRRK2PDCD1CD274CCNCCDK8 | |
| SCHEMBL164222 | 0.77 | MAPK14 (0.44) | PDCD1CD274BCL3PTGER1ALDH1A1 | |
| SCHEMBL1647863 | 0.76 | LRRK2 (0.53) | LRRK2ENPP2WDR5 | |
| SCHEMBL10323492 | 0.75 | HSD17B10 (0.47) | LRRK2ALDH1A1 | |
| SCHEMBL167588 | 0.73 | LRRK2 (0.67) | LRRK2CCNCCDK8CDK19 | |
| SCHEMBL10192760 | 0.71 | LRRK2 (0.54) | LRRK2CCNCCDK8CDK19 | |
| SCHEMBL166755 | 0.71 | HCRTR1 (0.47) | LRRK2CCNCCDK8CDK19ENPP2 | |
| SCHEMBL256260 | 0.70 | LRRK2 (0.46) | LRRK2FGFR3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012028629-A1 | 2 - (BENZYLOXY) BENZAMIDES AS LRRK2 KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2012-03-08 | — | — | WO | disclosed |