Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNK2 | Q07912 | 14/20 | 0.38 |
| ▸ | PLK4 | O00444 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | PAK4 | O96013 | 1/20 | 0.37 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.37 |
| ▸ | INSR | P06213 | 1/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | FYN | P06241 | 1/20 | 0.37 |
| ▸ | CSF1R | P07333 | 1/20 | 0.37 |
| ▸ | LYN | P07948 | 1/20 | 0.37 |
| ▸ | IGF1R | P08069 | 1/20 | 0.37 |
| ▸ | MET | P08581 | 1/20 | 0.37 |
| ▸ | KIT | P10721 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25715609 | 0.88 | TNK2 (0.37) | TNK2PLK4AURKADAPK3ROCK2 | |
| SCHEMBL25715486 | 0.87 | FGFR1 (0.44) | TNK2PLK4AURKADAPK3ROCK2 | |
| SCHEMBL25714868 | 0.84 | KDR (0.39) | TNK2PLK4AURKADAPK3ROCK2 | |
| SCHEMBL25715613 | 0.84 | KDR (0.45) | TNK2PLK4AURKADAPK3ROCK2 | |
| SCHEMBL25715555 | 0.82 | SRC (0.41) | TNK2PLK4AURKADAPK3ROCK2 | |
| SCHEMBL25715608 | 0.79 | TNK2 (0.39) | TNK2 | |
| SCHEMBL25715485 | 0.74 | CYP2C9 (0.45) | TNK2METFGFR1FGFR3KDM4E | |
| SCHEMBL22677266 | 0.72 | CYP3A4 (0.55) | LCKFGFR1SRCFGFR3KDR | |
| SCHEMBL25714867 | 0.72 | MAP4K4 (0.40) | TNK2PLK4AURKADAPK3ROCK2 | |
| SCHEMBL31213987 | 0.71 | TNK2 (0.41) | TNK2ABL1FGFR1SRCFGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023104035-A1 | SUBSTITUTED MONOCYCLIC OR BICYCLIC HETEROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | 英矽智能科技(上海)有限公司 | 2023-06-15 | — | — | WO | disclosed |