Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.41 |
| ▸ | AXL | P30530 | 2/20 | 0.39 |
| ▸ | MERTK | Q12866 | 2/20 | 0.39 |
| ▸ | CCNC | P24863 | 4/20 | 0.39 |
| ▸ | CDK8 | P49336 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | MET | P08581 | 1/20 | 0.34 |
| ▸ | TRPC6 | Q9Y210 | 2/20 | 0.34 |
| ▸ | BRD4 | O60885 | 2/20 | 0.34 |
| ▸ | TAF1 | P21675 | 2/20 | 0.34 |
| ▸ | CECR2 | Q9BXF3 | 2/20 | 0.34 |
| ▸ | BRD9 | Q9H8M2 | 2/20 | 0.34 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL165531 | 0.82 | LRRK2 (0.46) | LRRK2AXLMERTKCCNCCDK8 | |
| SCHEMBL15204962 | 0.80 | LRRK2 (0.55) | LRRK2AXLMERTKNPC1RAB9A | |
| SCHEMBL176062 | 0.79 | LRRK2 (0.54) | LRRK2 | |
| SCHEMBL176196 | 0.78 | LRRK2 (0.68) | LRRK2MET | |
| SCHEMBL166133 | 0.78 | LRRK2 (0.44) | LRRK2AXLMERTKCCNCCDK8 | |
| SCHEMBL165714 | 0.78 | LRRK2 (0.53) | LRRK2NPC1RAB9AGSK3BDYRK1A | |
| SCHEMBL175878 | 0.76 | LRRK2 (0.54) | LRRK2 | |
| SCHEMBL175796 | 0.76 | LRRK2 (0.68) | LRRK2MET | |
| SCHEMBL257050 | 0.75 | LRRK2 (0.51) | LRRK2MET | |
| SCHEMBL165664 | 0.75 | HSD17B10 (0.49) | LRRK2AXLMERTKCCNCCDK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012028629-A1 | 2 - (BENZYLOXY) BENZAMIDES AS LRRK2 KINASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2012-03-08 | — | — | WO | disclosed |