Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1H | O95180 | 2/20 | 0.41 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.38 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
| ▸ | PTGES | O14684 | 11/20 | 0.34 |
| ▸ | RHEB | Q15382 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | PRNP | P04156 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
| ▸ | USP1 | O94782 | 1/20 | 0.32 |
| ▸ | WDR48 | Q8TAF3 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25719300 | 0.86 | CACNA1H (0.37) | CACNA1HCACNA1GTRPA1TRPM8TRPV1 | |
| SCHEMBL30116510 | 0.83 | CACNA1H (0.39) | CACNA1HCACNA1GTRPA1TRPM8TRPV1 | |
| SCHEMBL25716483 | 0.83 | CACNA1H (0.39) | CACNA1HCACNA1GTRPA1TRPM8TRPV1 | |
| SCHEMBL30116437 | 0.83 | RORC (0.40) | CACNA1HCACNA1GTRPA1TRPM8TRPV1 | |
| SCHEMBL23000519 | 0.83 | CACNA1H (0.39) | CACNA1HCACNA1GTRPA1TRPM8TRPV1 | |
| SCHEMBL23000359 | 0.83 | RORC (0.40) | CACNA1HCACNA1GTRPA1TRPM8TRPV1 | |
| SCHEMBL25716635 | 0.83 | CACNA1H (0.39) | CACNA1HCACNA1GTRPA1TRPM8TRPV1 | |
| SCHEMBL30116413 | 0.82 | RORC (0.45) | CACNA1HCACNA1GPTGESHSD11B1CYP2C9 | |
| SCHEMBL23000320 | 0.82 | RORC (0.45) | CACNA1HCACNA1GPTGESHSD11B1CYP2C9 | |
| SCHEMBL25718660 | 0.81 | CACNA1H (0.38) | CACNA1HCACNA1GTRPA1TRPM8TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3781161-B1 | BENZIMIDAZOLE DERIVATIVES AS MODULATORS OF RETINOID-RELATED ORPHAN RECEPTOR GAMMA (RORY) AND PHARMACEUTICAL USES THEREOF | JIANGSU HENGRUI PHARMACEUTICALS CO LTD (CN) | 2023-06-07 | — | — | EP | disclosed |