Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 2/20 | 0.61 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.61 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.61 |
| ▸ | NQO1 | P15559 | 1/20 | 0.54 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.52 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | WDR5 | P61964 | 1/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.47 |
| ▸ | F2 | P00734 | 1/20 | 0.46 |
| ▸ | TMPRSS6 | Q8IU80 | 1/20 | 0.46 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.46 |
| ▸ | LTA4H | P09960 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14599600 | 0.84 | PRSS1 (0.48) | PRSS1PRSS2PRSS3WDR5F2 | |
| SCHEMBL14599522 | 0.81 | PRMT1 (0.61) | PRSS1ADRA2AF2ST14 | |
| SCHEMBL14599578 | 0.81 | PRMT1 (0.61) | PRSS1ADRA2AF2ST14 | |
| SCHEMBL700166 | 0.81 | PARP10 (0.61) | NQO1PARP10TSHRTDP1ALDH1A1 | |
| SCHEMBL5729248 | 0.80 | IDO1 (0.61) | PRSS1PRSS2PRSS3TSHRALDH1A1 | |
| Hydrochloric Acid SCHEMBL1021455 | 0.78 | IDO1 (0.62) | PRSS1PRSS2PRSS3TSHRALDH1A1 | |
| SCHEMBL15149741 | 0.78 | PRSS1 (0.52) | PRSS1PRSS2PRSS3ADRA2AF2 | |
| SCHEMBL6650453 | 0.78 | NQO1 (0.61) | PRSS1PRSS2PRSS3NQO1PARP10 | |
| SCHEMBL20008634 | 0.77 | IDO1 (0.57) | PRSS1PRSS2PRSS3ALDH1A1F2 | |
| SCHEMBL6709316 | 0.77 | NQO1 (0.54) | NQO1PARP10TDP1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120289502-A1 | IMIDAZOLE DERIVATIVES | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2012-11-15 | — | — | US | disclosed |
| US-8273738-B2 | Imidazole derivatives | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2012-09-25 | — | — | US | disclosed |
| CN-101511796-B | Imidazole derivatives | KYOWA HAKKO KOGYO KK | 2012-05-09 | — | — | CN | disclosed |
| EP-2090570-B1 | IMIDAZOLE DERIVATIVE | KYOWA HAKKO KIRIN CO LTD (JP) | 2011-11-09 | — | — | EP | disclosed |
| US-20100152178-A1 | IMIDAZOLE DERIVATIVES | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2010-06-17 | — | — | US | disclosed |
| EP-2090570-A1 | IMIDAZOLE DERIVATIVE | Kyowa Hakko Kirin Co., Ltd. (JP) | 2009-08-19 | — | — | EP | disclosed |
| CN-101511796-A | Imidazole derivative | KYOWA HAKKO KOGYO KK (JP) | 2009-08-19 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120289502-A1 | IMIDAZOLE DERIVATIVES | CNR1, CNR2, ARRB1 | PRSS1 3856/4885PRSS2 4037/4885PRSS3 4331/4885 |
| US-20100152178-A1 | IMIDAZOLE DERIVATIVES | CNR1, CNR2, ARRB1 | PRSS1 3856/4885PRSS2 4037/4885PRSS3 4331/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.