Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | NQO1 | P15559 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.54 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.54 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.54 |
| ▸ | CNR1 | P21554 | 1/20 | 0.54 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.54 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.54 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | GLA | P06280 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.54 |
| ▸ | THPO | P40225 | 1/20 | 0.54 |
| ▸ | BLM | P54132 | 1/20 | 0.54 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31215186 | 0.87 | LMNA (0.50) | PARP10LMNATDP1ADRB2ADRB1 | |
| SCHEMBL31215188 | 0.87 | LMNA (0.50) | PARP10LMNATDP1ADRB2ADRB1 | |
| SCHEMBL29639820 | 0.85 | LMNA (0.58) | ALDH1A1LMNAKDM4ECYP1A2 | |
| SCHEMBL21700175 | 0.85 | KDM4E (0.66) | ALDH1A1LMNAKDM4ECYP1A2 | |
| SCHEMBL11201567 | 0.83 | NPSR1 (0.59) | ALDH1A1TDP1KDM4E | |
| SCHEMBL31215187 | 0.83 | KDM4E (0.51) | ALDH1A1LMNATDP1ADRB2ADRB1 | |
| SCHEMBL7601684 | 0.82 | CA2 (0.55) | PARP10LMNATDP1ADRB2ADRB1 | |
| SCHEMBL503308 | 0.82 | PLA2G4B (0.58) | PARP10ALDH1A1NQO1TDP1CA2 | |
| SCHEMBL2628188 | 0.82 | POLB (0.59) | PARP10ALDH1A1NQO1LMNATDP1 | |
| SCHEMBL22282965 | 0.81 | PARP10 (0.58) | PARP10ALDH1A1NQO1LMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 96 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074089-B1 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2013-09-18 | — | — | EP | claimed |
| US-8222248-B2 | Organic compounds | NOVARTIS AG (CH) | 2012-07-17 | — | — | US | claimed |
| US-7968591-B2 | 1,3-disubstituted 4-methyl-1H-pyrrole-2-carboxamides and their use in medicaments | GRUENENTHAL GMBH (DE) | 2011-06-28 | — | — | US | claimed |
| EP-2035375-B1 | 1,3-DISUBSTITUTED 4-METHYL-1H-PYRROLE-2-CARBOXAMIDES AND THEIR USE FOR THE MANUFACTURE OF MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2011-01-19 | — | — | EP | claimed |
| EP-2074089-A2 | ORGANIC COMPOUNDS | Novartis AG (CH) | 2009-07-01 | — | — | EP | claimed |
| US-20090137573-A1 | 1,3-Disubstituted 4-methyl-1H-pyrrole-2-carboxamides and their Use in Medicaments | GRUENENTHAL GMBH (DE) | 2009-05-28 | — | — | US | claimed |
| WO-2008048991-A2 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2008-04-24 | — | — | WO | claimed |
| CN-1250607-C | Method for anionic polymerization of lactames | ATOFINA (FR) | 2006-04-12 | — | — | CN | claimed |
| EP-1377589-B1 | OXAZOLYL-PYRAZOLE DERIVATIVES AS KINASE INHIBITORS | PHARMACIA ITALIA SPA (IT) | 2005-09-07 | — | — | EP | claimed |
| EP-1191050-B1 | Anionic polymerization process of lactams | ARKEMA (FR) | 2005-01-26 | — | — | EP | claimed |
| WO-2004018461-A2 | ANTIBACTERIAL BENZOIC ACID DERIVATIVES | PHARMACIA & UPJOHN COMPANY LLC (US) | 2004-03-04 | — | — | WO | claimed |
| EP-1165661-B1 | METHOD FOR ANIONIC POLYMERIZATION OF LACTAMES | ATOFINA (FR) | 2004-02-04 | — | — | EP | claimed |
| EP-1377589-A1 | OXAZOLYL-PYRAZOLE DERIVATIVES AS KINASE INHIBITORS | Pharmacia Italia S.p.A. (IT) | 2004-01-07 | — | — | EP | claimed |
| US-6579965-B2 | Process for the anionic polymerization of lactams | ATOFINA (FR) | 2003-06-17 | — | — | US | claimed |
| US-20020161167-A1 | Process for the anionic polymerization of lactams | ATOFINA (FR) | 2002-10-31 | — | — | US | claimed |
| WO-2002062804-A1 | OXAZOLYL-PYRAZOLE DERIVATIVES AS KINASE INHIBITORS | PHARMACIA ITALIA S.P.A. (IT) | 2002-08-15 | — | — | WO | claimed |
| CN-1351623-A | Method for anionic polymerization of lactames | ATOFINA (FR) | 2002-05-29 | — | — | CN | claimed |
| EP-1191050-A1 | Anionic polymerization process of lactams | Atofina (FR) | 2002-03-27 | — | — | EP | claimed |
| EP-1165661-A1 | METHOD FOR ANIONIC POLYMERIZATION OF LACTAMES | Atofina (FR) | 2002-01-02 | — | — | EP | claimed |
| WO-2000058387-A1 | METHOD FOR ANIONIC POLYMERIZATION OF LACTAMES | ATOFINA (FR) | 2000-10-05 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090137573-A1 | 1,3-Disubstituted 4-methyl-1H-pyrrole-2-carboxamides and their Use in Medicaments | OPRL1, TPH1, OPRK1 | PARP10 809/4885ALDH1A1 2168/4885NQO1 2153/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.