Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 18/20 | 0.66 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | JAK3 | P52333 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2572103 | 1.00 | NTRK1 (0.66) | NTRK1JAK2JAK3 | |
| SCHEMBL27856027 | 0.93 | NTRK1 (0.64) | NTRK1JAK2JAK3 | |
| SCHEMBL2565272 | 0.93 | NTRK1 (0.64) | NTRK1JAK2JAK3 | |
| SCHEMBL4072344 | 0.87 | NTRK1 (0.80) | NTRK1 | |
| SCHEMBL27856020 | 0.86 | NTRK1 (0.71) | NTRK1JAK2JAK3 | |
| SCHEMBL2566970 | 0.86 | NTRK1 (0.71) | NTRK1JAK2JAK3 | |
| SCHEMBL2634646 | 0.85 | NTRK1 (0.72) | NTRK1JAK2JAK3 | |
| SCHEMBL4694176 | 0.85 | NTRK1 (0.77) | NTRK1JAK2JAK3 | |
| SCHEMBL2567488 | 0.85 | NTRK1 (0.77) | NTRK1JAK2JAK3 | |
| SCHEMBL22535653 | 0.85 | NTRK1 (0.63) | NTRK1JAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101155800-B | Pyrazolylaminopyridine derivatives useful as kinase inhibitors | ASTRAZENECA AB | 2012-05-23 | — | — | CN | disclosed |
| EP-2383268-A1 | Pyrazolylaminopyridine derivatives useful as kinase inhibitors | AstraZeneca AB (SE) | 2011-11-02 | — | — | EP | disclosed |