Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 17/20 | 0.63 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | JAK3 | P52333 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22535313 | 0.90 | NTRK1 (0.63) | NTRK1JAK2JAK3 | |
| SCHEMBL22535630 | 0.88 | NTRK1 (0.66) | NTRK1JAK2JAK3 | |
| SCHEMBL22535401 | 0.86 | NTRK1 (0.65) | NTRK1JAK2JAK3 | |
| SCHEMBL22535451 | 0.85 | NTRK1 (0.67) | NTRK1JAK2JAK3 | |
| SCHEMBL2565272 | 0.85 | NTRK1 (0.64) | NTRK1JAK2JAK3 | |
| SCHEMBL2572107 | 0.85 | NTRK1 (0.66) | NTRK1JAK2JAK3 | |
| SCHEMBL27856027 | 0.85 | NTRK1 (0.64) | NTRK1JAK2JAK3 | |
| SCHEMBL2572103 | 0.85 | NTRK1 (0.66) | NTRK1JAK2JAK3 | |
| SCHEMBL27658349 | 0.83 | NTRK1 (0.59) | NTRK1JAK2JAK3 | |
| SCHEMBL4697728 | 0.83 | NTRK1 (0.59) | NTRK1JAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10800760-B2 | Trk inhibition | NANTBIO, INC. (US) | 2020-10-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10800760-B2 | Trk inhibition | NTRK1, NTRK3, NTRK2 | NTRK1 1/4885JAK2 833/4885JAK3 649/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.