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SCHEMBL25735971

SCHEMBL25735971

CNc1ncc2c(n1)N(C)C(=O)N(c1cc(NC(=O)c3ccc(CN4CCC(N5CCCCC5)CC4)c(C(F)(F)F)c3)ccc1C)C2

nearest known ligand 0.70

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TNK2 Q07912 18/20 0.70
▸ MAP4K2 Q12851 18/20 0.70
▸ BMX P51813 3/20 0.58
▸ ABL1 P00519 4/20 0.57
▸ LCK P06239 1/20 0.54
▸ FES P07332 1/20 0.54
▸ RET P07949 1/20 0.54
▸ PDGFRB P09619 1/20 0.54
▸ KIT P10721 1/20 0.54
▸ FGFR1 P11362 1/20 0.54
▸ SRC P12931 1/20 0.54
▸ PDGFRA P16234 1/20 0.54
▸ FLT1 P17948 1/20 0.54
▸ FGFR3 P22607 1/20 0.54
▸ EPHA3 P29320 1/20 0.54
▸ KDR P35968 1/20 0.54
▸ EPHB4 P54760 1/20 0.54
▸ TEK Q02763 1/20 0.54
▸ KARS1 Q15046 1/20 0.54
▸ NTRK3 Q16288 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3139861 0.93 TNK2 (0.78) TNK2MAP4K2BMXABL1LCK
SCHEMBL3134211 0.91 TNK2 (0.84) TNK2MAP4K2BMXABL1LCK
SCHEMBL3139682 0.89 MAP4K2 (0.78) TNK2MAP4K2BMXABL1
SCHEMBL3139872 0.89 TNK2 (0.75) TNK2MAP4K2BMXABL1LCK
SCHEMBL3137490 0.87 TNK2 (0.68) TNK2MAP4K2BMXABL1LCK
SCHEMBL3134784 0.85 TNK2 (0.73) TNK2MAP4K2BMXABL1LCK
SCHEMBL13523236 0.84 TNK2 (0.64) TNK2MAP4K2BMXABL1LCK
SCHEMBL27056968 0.83 TNK2 (0.67) TNK2MAP4K2BMXABL1BCR
SCHEMBL25735972 0.83 TNK2 (0.67) TNK2MAP4K2BMXABL1BCR
SCHEMBL3143346 0.83 TNK2 (0.67) TNK2MAP4K2BMXABL1LCK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240024490-A1 BIFUNCTIONAL MOLECULES FOR SELECTIVE MODIFICATION OF TARGET SUBSTRATES THE BROAD INSTITUTE, INC. 2024-01-25 — — US disclosed
US-20240024490-A1 BIFUNCTIONAL MOLECULES FOR SELECTIVE MODIFICATION OF TARGET SUBSTRATES THE BROAD INSTITUTE, INC. 2024-01-25 — — US disclosed
US-20230192904-A1 BIFUNCTIONAL CHIMERIC MOLECULES FOR LABELING OF KINASES WITH TARGET BINDING MOIETIES AND METHODS OF USE THEREOF THE BROAD INSTITUTE, INC. 2023-06-22 — — US disclosed
US-20230192904-A1 BIFUNCTIONAL CHIMERIC MOLECULES FOR LABELING OF KINASES WITH TARGET BINDING MOIETIES AND METHODS OF USE THEREOF THE BROAD INSTITUTE, INC. 2023-06-22 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240024490-A1 BIFUNCTIONAL MOLECULES FOR SELECTIVE MODIFICATION OF TARGET SUBSTRATES COASY, JMJD7, PTMS TNK2 773/4885MAP4K2 2147/4885BMX 344/4885
US-20230192904-A1 BIFUNCTIONAL CHIMERIC MOLECULES FOR LABELING OF KINASES WITH TARGET BINDING MOIETIES AND METHODS OF USE THEREOF ERBB2, ACP1, TK1 TNK2 50/4885MAP4K2 82/4885BMX 7/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.