Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | YES1 | P07947 | 3/20 | 0.53 |
| ▸ | SRC | P12931 | 3/20 | 0.53 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.53 |
| ▸ | AURKA | O14965 | 4/20 | 0.51 |
| ▸ | BRAF | P15056 | 9/20 | 0.50 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.50 |
| ▸ | LCK | P06239 | 1/20 | 0.48 |
| ▸ | MAP3K5 | Q99683 | 2/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.46 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2573807 | 0.88 | SRC (0.53) | YES1SRCBRAFFGFR4LCK | |
| SCHEMBL5501445 | 0.80 | MAP4K1 (0.64) | SRCFGFR4FGFR1 | |
| SCHEMBL226380 | 0.80 | STK17A (0.58) | FGFR4PDGFRBFGFR1PDGFRA | |
| SCHEMBL229526 | 0.79 | ALK (0.59) | — | |
| SCHEMBL230249 | 0.77 | SRC (0.77) | YES1SRCEPHB4BRAFLCK | |
| SCHEMBL230101 | 0.75 | BRAF (0.50) | SRCEPHB4BRAF | |
| SCHEMBL5501154 | 0.75 | SRC (0.69) | YES1SRCEPHB4BRAFLCK | |
| SCHEMBL12999378 | 0.75 | AURKA (0.60) | YES1SRCEPHB4AURKA | |
| SCHEMBL4030061 | 0.74 | MAP3K5 (0.55) | AURKAMAP3K5 | |
| SCHEMBL31006394 | 0.74 | RIPK2 (0.62) | BRAFMAP3K5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2381943-A1 | SUBSTITUTED QUINAZOLINE COMPOUNDS | Fovea Pharmaceuticals (FR) | 2011-11-02 | — | — | EP | disclosed |
| WO-2010076238-A1 | SUBSTITUTED QUINAZOLINE COMPOUNDS | FOVEA PHARMACEUTICALS SA (FR) | 2010-07-08 | — | — | WO | disclosed |