Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 3/20 | 0.53 |
| ▸ | YES1 | P07947 | 1/20 | 0.53 |
| ▸ | BRAF | P15056 | 13/20 | 0.50 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.50 |
| ▸ | LCK | P06239 | 1/20 | 0.48 |
| ▸ | MAP3K5 | Q99683 | 2/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.44 |
| ▸ | WEE1 | P30291 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2573809 | 0.88 | YES1 (0.53) | SRCYES1BRAFFGFR4LCK | |
| SCHEMBL5501445 | 0.80 | MAP4K1 (0.64) | SRCFGFR4FGFR1WEE1 | |
| SCHEMBL226380 | 0.80 | STK17A (0.58) | FGFR4FGFR1WEE1 | |
| SCHEMBL229526 | 0.79 | ALK (0.59) | WEE1 | |
| SCHEMBL230249 | 0.77 | SRC (0.77) | SRCYES1BRAFLCKFGFR1 | |
| SCHEMBL230101 | 0.75 | BRAF (0.50) | SRCBRAF | |
| SCHEMBL5501154 | 0.75 | SRC (0.69) | SRCYES1BRAFLCKFGFR1 | |
| SCHEMBL231133 | 0.74 | SRC (0.51) | SRCYES1BRAFLCKFGFR1 | |
| SCHEMBL2582023 | 0.73 | SRC (0.53) | SRCYES1BRAFLCKMAP3K5 | |
| SCHEMBL42089 | 0.73 | LCK (0.73) | SRCLCKFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2381943-A1 | SUBSTITUTED QUINAZOLINE COMPOUNDS | Fovea Pharmaceuticals (FR) | 2011-11-02 | — | — | EP | disclosed |
| WO-2010076238-A1 | SUBSTITUTED QUINAZOLINE COMPOUNDS | FOVEA PHARMACEUTICALS SA (FR) | 2010-07-08 | — | — | WO | disclosed |