Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNK2 | Q07912 | 15/20 | 0.48 |
| ▸ | RAF1 | P04049 | 1/20 | 0.46 |
| ▸ | SRC | P12931 | 1/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.44 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.44 |
| ▸ | MTOR | P42345 | 1/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.44 |
| ▸ | PRKDC | P78527 | 1/20 | 0.44 |
| ▸ | RICTOR | Q6R327 | 1/20 | 0.44 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.44 |
| ▸ | MAPKAP1 | Q9BPZ7 | 1/20 | 0.44 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.44 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.44 |
| ▸ | BTK | Q06187 | 1/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.44 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.44 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28911444 | 0.93 | FGFR4 (0.49) | TNK2RAF1SRCFGFR2BTK | |
| SCHEMBL28911445 | 0.93 | FGFR4 (0.49) | TNK2RAF1SRCFGFR2BTK | |
| SCHEMBL4357539 | 0.85 | TNK2 (0.64) | TNK2RAF1SRCPIK3CAPIK3CB | |
| SCHEMBL28911435 | 0.82 | FGFR4 (0.62) | TNK2FGFR2BTKFGFR1FGFR4 | |
| SCHEMBL24251869 | 0.82 | FGFR4 (0.62) | TNK2FGFR2BTKFGFR1FGFR4 | |
| SCHEMBL398874 | 0.82 | FGFR2 (0.57) | TNK2FGFR2FGFR1 | |
| SCHEMBL594940 | 0.82 | TNK2 (0.59) | TNK2PIK3CAPIK3CBMTORPIK3CG | |
| SCHEMBL594938 | 0.82 | TNK2 (0.59) | TNK2PIK3CAPIK3CBMTORPIK3CG | |
| SCHEMBL593894 | 0.82 | IGF1R (0.51) | TNK2 | |
| SCHEMBL26791421 | 0.80 | TNK2 (0.59) | TNK2RAF1SRCFGFR2BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2385053-A2 | Intermediates for the preparation of fused bicyclic mTOR inhibitors | OSI Pharmaceuticals, Inc. (US) | 2011-11-09 | — | — | EP | disclosed |