Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 7/20 | 0.62 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.62 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.56 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | JAK3 | P52333 | 1/20 | 0.45 |
| ▸ | BTK | Q06187 | 6/20 | 0.45 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24251869 | 1.00 | FGFR4 (0.62) | FGFR4FGFR1FGFR2FGFR3EGFR | |
| SCHEMBL28911445 | 0.87 | FGFR4 (0.49) | FGFR4FGFR1FGFR2FGFR3BTK | |
| SCHEMBL28911444 | 0.87 | FGFR4 (0.49) | FGFR4FGFR1FGFR2FGFR3BTK | |
| SCHEMBL2574101 | 0.82 | TNK2 (0.48) | FGFR4FGFR1FGFR2FGFR3BTK | |
| SCHEMBL26820282 | 0.81 | TNK2 (0.59) | FGFR4FGFR1FGFR2FGFR3BTK | |
| SCHEMBL26791421 | 0.81 | TNK2 (0.59) | FGFR4FGFR1FGFR2FGFR3BTK | |
| SCHEMBL29388063 | 0.80 | FGFR4 (0.41) | FGFR4FGFR1FGFR2FGFR3TNK2 | |
| SCHEMBL30101135 | 0.80 | FGFR4 (0.58) | FGFR4FGFR1FGFR2EGFRBTK | |
| SCHEMBL30515956 | 0.78 | FGFR4 (0.72) | FGFR4FGFR1FGFR2FGFR3BTK | |
| SCHEMBL30101111 | 0.78 | TNK2 (0.61) | FGFR4FGFR1FGFR2BTKTNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115485281-B | FGFR and mutation inhibitor thereof, and preparation method and application thereof | 上海和誉生物医药科技有限公司 | 2023-11-21 | — | — | CN | disclosed |
| CN-115485281-A | FGFR and mutation inhibitor thereof, and preparation method and application thereof | 上海和誉生物医药科技有限公司 | 2022-12-16 | — | — | CN | disclosed |