Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.44 |
| ▸ | CTSD | P07339 | 7/20 | 0.40 |
| ▸ | BACE2 | Q9Y5Z0 | 6/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7713684 | 0.83 | BACE1 (0.64) | BACE1CTSDBACE2KCNH2 | |
| SCHEMBL2574130 | 0.77 | BACE1 (0.66) | BACE1CTSDBACE2KCNH2 | |
| SCHEMBL2572112 | 0.74 | BACE1 (0.73) | BACE1CTSDBACE2 | |
| SCHEMBL2572115 | 0.74 | BACE1 (0.73) | BACE1CTSDBACE2 | |
| SCHEMBL7711604 | 0.73 | BACE1 (0.67) | BACE1CTSDBACE2 | |
| SCHEMBL2573768 | 0.72 | BACE1 (0.54) | BACE1CTSD | |
| SCHEMBL2573986 | 0.72 | BACE1 (0.64) | BACE1CTSDBACE2 | |
| SCHEMBL7713041 | 0.71 | BACE1 (0.57) | BACE1CTSDBACE2 | |
| SCHEMBL8513094 | 0.71 | BACE1 (0.63) | BACE1CTSDBACE2 | |
| SCHEMBL7712093 | 0.70 | BACE1 (0.65) | BACE1CTSDBACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011130741-A1 | COMPOUNDS FOR TREATING NEURODEGENERATIVE DISEASES | ARRAY BIOPHARMA INC. (US) | 2011-10-20 | — | — | WO | disclosed |