⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24768869 | 0.79 | — | — | |
| SCHEMBL25744940 | 0.78 | SMN1; SMN2 (0.31) | — | |
| SCHEMBL25744942 | 0.78 | — | — | |
| SCHEMBL25625900 | 0.76 | HTT (0.35) | — | |
| SCHEMBL25857845 | 0.76 | KMT2A (0.34) | — | |
| SCHEMBL19219033 | 0.75 | ADORA2A (0.32) | — | |
| SCHEMBL25744941 | 0.75 | — | — | |
| SCHEMBL25619102 | 0.74 | SMN1; SMN2 (0.33) | — | |
| SCHEMBL24768980 | 0.74 | ACVRL1 (0.30) | — | |
| SCHEMBL24768960 | 0.73 | TLR9 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230357254-A1 | IMIDAZOPYRIDAZINES AS MODULATORS OF IL-17 | JANSSEN PHARMACEUTICA NV (BE) | 2023-11-09 | — | — | US | disclosed |
| US-11702422-B2 | Imidazopyridazines as modulators of IL-17 | JANSSEN PHARMACEUTICA NV (BE) | 2023-07-18 | — | — | US | disclosed |
| US-11691979-B2 | Imidazopyridazines as modulators of IL-17 | JANSSEN PHARMACEUTICA NV (BE) | 2023-07-04 | — | — | US | disclosed |