Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 17/20 | 0.43 |
| ▸ | HTR2B | P41595 | 17/20 | 0.43 |
| ▸ | HTR2A | P28223 | 6/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | ABL2 | P42684 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2016192 | 1.00 | HTR2C (0.43) | HTR2CHTR2BHTR2AOPRM1ABL1 | |
| SCHEMBL692898 | 0.91 | HTR2C (0.43) | HTR2CHTR2BHTR2AOPRM1ABL1 | |
| SCHEMBL2020139 | 0.90 | HTR2C (0.41) | HTR2CHTR2BHTR2A | |
| SCHEMBL2576587 | 0.89 | HTR2C (0.49) | HTR2CHTR2BHTR2A | |
| SCHEMBL2013664 | 0.89 | HTR2C (0.49) | HTR2CHTR2BHTR2A | |
| SCHEMBL2562895 | 0.87 | HTR2C (0.46) | HTR2CHTR2BHTR2A | |
| SCHEMBL2021535 | 0.87 | HTR2C (0.48) | HTR2CHTR2BHTR2A | |
| SCHEMBL2572350 | 0.87 | HTR2C (0.48) | HTR2CHTR2BHTR2A | |
| SCHEMBL2016529 | 0.87 | HTR2C (0.46) | HTR2CHTR2BHTR2A | |
| SCHEMBL2582057 | 0.84 | HTR2C (0.40) | HTR2CHTR2BHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2560973-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | Abbvie Inc. (US) | 2013-02-27 | — | — | EP | claimed |
| WO-2011133182-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2011-10-27 | — | — | WO | claimed |
| EP-2560973-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | Abbvie Inc. (US) | 2013-02-27 | — | — | EP | disclosed |
| WO-2011133182-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2011-10-27 | — | — | WO | disclosed |