SCHEMBL257522

SCHEMBL257522

COCc1nn2c(-c3cccc(C(F)(F)F)c3)cc(=O)[nH]c2c1-c1ccc(OC)cc1

nearest known ligand 0.62

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
PLAT P00750 6/20 0.62
ARF6 P62330 7/20 0.47
NR1H4 Q96RI1 1/20 0.40
DYRK3 O43781 1/20 0.39
CCNT1 O60563 1/20 0.39
CCNA2 P20248 1/20 0.39
CDK2 P24941 1/20 0.39
CDK9 P50750 1/20 0.39
CDK5 Q00535 1/20 0.39
DYRK1A Q13627 1/20 0.39
CDK5R1 Q15078 1/20 0.39
DYRK2 Q92630 1/20 0.39
DYRK1B Q9Y463 1/20 0.39
RPS6KB1 P23443 1/20 0.39
RAB9A P51151 1/20 0.39
GRIN1 Q05586 1/20 0.39
GRIN2B Q13224 1/20 0.39
XDH P47989 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15020609 0.92 PLAT (0.55) PLATARF6RAB9AXDH
SCHEMBL256819 0.87 PLAT (0.64) PLATARF6NR1H4DYRK3CCNT1
SCHEMBL15020930 0.79 MAPT (0.43) PLATNR1H4DYRK3CCNT1CCNA2
SCHEMBL257326 0.77 PLAT (0.68) PLATARF6XDH
SCHEMBL17737866 0.77 PLAT (1.00) PLAT
Hydrochloric Acid SCHEMBL21173732 0.76 PLAT (0.98) PLAT
SCHEMBL16556559 0.74 PLAT (0.47) PLATARF6
SCHEMBL15021448 0.74 MAPT (0.39) PLATNR1H4DYRK3CCNT1CCNA2
SCHEMBL257699 0.72 MAPT (0.60) PLATRAB9A
SCHEMBL17738053 0.71 PLAT (1.00) PLAT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8975264-B2 Compound acting as a cannabinoid receptor-1 inhibitor AMOREPACIFIC CORPORATION (KR) 2015-03-10 US disclosed
US-20130158025-A1 NOVEL COMPOUND ACTING AS A CANNABINOID RECEPTOR-1 INHIBITOR AMOREPACIFIC CORPORATION (KR) 2013-06-20 US disclosed
WO-2012030170-A2 NOVEL COMPOUND ACTING AS A CANNABINOID RECEPTOR-1 INHIBITOR (주)아모레퍼시픽 (KR) 2012-03-08 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130158025-A1 NOVEL COMPOUND ACTING AS A CANNABINOID RECEPTOR-1 INHIBITOR CNR1, CNR2, GPR18 PLAT 3840/4885ARF6 1261/4885NR1H4 191/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.