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Sugi Predict / Targets / GPR18

GPR18

N-arachidonyl glycine receptor · Q14330 · GPR18 on Sugi Atlas →

6,301 patent compounds predicted against GPR18, 4,858 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL2404679 SCHEMBL2404679 0.57 13/20
SCHEMBL1781382 SCHEMBL1781382 0.51 11/20
SCHEMBL3008427 SCHEMBL3008427 0.53 5/20
SCHEMBL3008431 SCHEMBL3008431 0.53 5/20
SCHEMBL2357902 SCHEMBL2357902 0.42 5/20
SCHEMBL2359435 SCHEMBL2359435 0.40 5/20
SCHEMBL2358698 SCHEMBL2358698 0.41 4/20
SCHEMBL3298491 SCHEMBL3298491 0.57 3/20
SCHEMBL3998746 SCHEMBL3998746 0.56 3/20
SCHEMBL3297145 SCHEMBL3297145 0.53 3/20
SCHEMBL4000390 SCHEMBL4000390 0.51 3/20
SCHEMBL1235919 SCHEMBL1235919 0.51 3/20
SCHEMBL3997465 SCHEMBL3997465 0.50 3/20
SCHEMBL244375 SCHEMBL244375 0.48 3/20
SCHEMBL244651 SCHEMBL244651 0.45 3/20
SCHEMBL2358849 SCHEMBL2358849 0.42 3/20
SCHEMBL3814378 SCHEMBL3814378 0.41 3/20
SCHEMBL1781326 SCHEMBL1781326 0.41 3/20
SCHEMBL2318495 SCHEMBL2318495 0.37 3/20
SCHEMBL2264675 SCHEMBL2264675 0.34 3/20

Clinical trials — most relevant to GPR18 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Treatment Strategies in CHS PHASE4COMPLETED
Indicated Prevention With Omega-3 Fatty Acids in Adolescents With 'At-Risk-Mental-State' for Psychosis PHASE4COMPLETED
Dronabinol in Trichotillomania and Other Body Focused Repetitive Behaviors PHASE2/PHASE3COMPLETED
A Series of Pilot Studies to Evaluate the haemoDynamic and mEtabolic Effects oF apelIn aNd rElaxin PHASE2UNKNOWN
Effect of Sarcosine on Symptomatology, Quality of Life, Oxidative Stress and Glutamatergic Parameters in Schizophrenia PHASE2COMPLETED
Effect of Hemp-CBD on Patients With CIPN PHASE2UNKNOWN
Neurobiology of a Mutation in Glycine Metabolism in Psychotic Disorders PHASE2COMPLETED
TRPM8 Activators for Peripheral Neuropathy PHASE2ACTIVE_NOT_RECRUITING
Preventive Effect of Acetyl-L-carnitine on Oxaliplatin-induced Peripheral Neuropathy PHASE2UNKNOWN
Sweet Taste Receptors and the Secretion of Glucagon-like Peptide-1 and Peptide YY PHASE1COMPLETED
The Role of Endocannabinoids in Insulin Production and Action PHASE1COMPLETED
First-In-Human Study of GFB-024 in Healthy Overweight and Obese Participants, and Participants With Type 2 Diabetes PHASE1COMPLETED
PET Imaging of Brain mGluR5 Receptors Using [18F]SP203 PHASE1COMPLETED
PET Imaging of Cannabinoid CB1 Receptors Using [18F]FMPEP-d2 PHASE1COMPLETED
Targeting a Genetic Mutation in Glycine Metabolism With D-cycloserine EARLY_PHASE1COMPLETED
Effects of Probiotics on Gut Microbiota, Endocannabinoid and Immune Activation and Symptoms of Fatigue in Dancers nanCOMPLETED
Acute Asthma Responsiveness and B2 Adrenergic Receptors Polymorphisms nanCOMPLETED
Comparison of Cannabinoids to Placebo in Management of TMJ Pain and Myofascial Pain in the TMJ Region nanCOMPLETED
The Impact of Pharmacological and Electric Modulation of NMDA Pathway on the Cognitive Flexibility and Volitional Movement Preparation in Patients With Parkinson's Disease nanCOMPLETED
Psychological and Biological Markers of Refractory Migraine nanUNKNOWN
Dose-response Effect of Pine Nut Oil as a Dual FFA1 and FFA4 Agonist on Glucose Tolerance in Healthy Humans. nanCOMPLETED
Metabotropic Receptors For Glutamate Type 3 In Parkinson's nanUNKNOWN
FFAR Agonist on Incretins, Insulin, Lipids and Inflammation nanCOMPLETED
Selective Activation of the Adrenomedullin Receptors in Migraine nanNOT_YET_RECRUITING
PET Imaging of Brain mGluR1 Receptors Using [18F]FIMX nanCOMPLETED
Effect of OMM on Anandamide Levels in Saliva nanCOMPLETED
Fat-induced Release of GLP-1 in Humans nanCOMPLETED
Modulatory Effects of Active Drugs on the Endocannabinoid System on Spontaneous and Induced Contractility of the Colon nanCOMPLETED
Gastric Bypass and Peripheral Activity of the Endocannabinoid System nanCOMPLETED
Effect of Dietary Oils as G-protein-coupled Receptor Agonists on Glucose Tolerance nanUNKNOWN

Related proteins — ESM-2 sequence neighbours (a GPR18 binder may also engage these)

ProteinNameSimilarity
Q4R613 — 1.000 Q4R613 →
Q3T0E9 — 1.000 Q3T0E9 →
A1A5S3 — 1.000 A1A5S3 →
Q8K1Z6 — 0.999 Q8K1Z6 →
Q9J529 — 0.995 Q9J529 →
Q9J5H4 — 0.993 Q9J5H4 →
P69333 — 0.992 P69333 →
P69332 — 0.992 P69332 →
Q96P67 — 0.991 Q96P67 →
Q89609 — 0.990 Q89609 →
Q8BZR0 — 0.990 Q8BZR0 →
F5HF62 — 0.990 F5HF62 →
P09703 — 0.989 P09703 →
Q0VDU3 — 0.988 Q0VDU3 →
F5HDK1 — 0.986 F5HDK1 →
P35351 — 0.986 P35351 →
Q9Z0Z6 — 0.986 Q9Z0Z6 →
P51676 — 0.985 P51676 →
SUCNR1 Succinate receptor 1 0.985 landscape →
Q86917 — 0.985 Q86917 →
Q3U507 — 0.985 Q3U507 →
P56412 — 0.984 P56412 →
Q0II78 — 0.984 Q0II78 →
Q01035 — 0.984 Q01035 →
A5PLE7 — 0.984 A5PLE7 →
P35374 — 0.983 P35374 →
P32229 — 0.983 P32229 →
Q9J5I0 — 0.983 Q9J5I0 →
Q99MT6 — 0.983 Q99MT6 →
Q9XSD7 — 0.983 Q9XSD7 →