Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 11/20 | 0.46 |
| ▸ | NPC1 | O15118 | 10/20 | 0.46 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ME2 | P23368 | 1/20 | 0.38 |
| ▸ | ME1 | P48163 | 1/20 | 0.38 |
| ▸ | ME3 | Q16798 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9747673 | 0.78 | ESR1 (0.47) | RAB9ANPC1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL30406600 | 0.76 | POLB (0.44) | POLBRAB9ANPC1PDE3BPDE3A | |
| SCHEMBL14916815 | 0.76 | POLB (0.44) | POLBRAB9ANPC1PDE3BPDE3A | |
| SCHEMBL14925500 | 0.73 | GAA (0.51) | RAB9ANPC1PDE3BPDE3AKMT2A | |
| SCHEMBL21815183 | 0.70 | KMT2A (0.68) | RAB9ANPC1KMT2AMEN1 | |
| SCHEMBL3999941 | 0.70 | ME2 (0.52) | POLBNPC1KMT2AME2ME1 | |
| SCHEMBL23188417 | 0.69 | GAA (0.59) | RAB9ANPC1KMT2AMEN1ALDH1A1 | |
| SCHEMBL21327663 | 0.69 | ME2 (0.52) | POLBKMT2AMEN1ALDH1A1HPGD | |
| SCHEMBL10964722 | 0.68 | MEN1 (0.61) | RAB9ANPC1KMT2AMEN1ALDH1A1 | |
| SCHEMBL22077654 | 0.68 | MAPT (0.47) | RAB9ANPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2555768-A2 | IRE-1 INHIBITORS | MannKind Corporation (US) | 2013-02-13 | — | — | EP | disclosed |
| WO-2011127070-A2 | IRE-1α INHIBITORS | MANNKIND CORPORATION (US) | 2011-10-13 | — | — | WO | disclosed |