Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 19/20 | 0.62 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.62 |
| ▸ | SCD | O00767 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2520485 | 0.85 | GPR119 (0.85) | GPR119KCNH2SCD | |
| SCHEMBL12213571 | 0.80 | GPR119 (0.75) | GPR119KCNH2SCD | |
| SCHEMBL2522929 | 0.78 | GPR119 (0.85) | GPR119KCNH2SCD | |
| SCHEMBL2521187 | 0.77 | GPR119 (0.79) | GPR119KCNH2 | |
| Bms-903452 SCHEMBL2518877 | 0.77 | GPR119 (1.00) | GPR119KCNH2SCD | |
| SCHEMBL2518871 | 0.74 | GPR119 (0.83) | GPR119KCNH2 | |
| SCHEMBL12213567 | 0.71 | GPR119 (0.89) | GPR119KCNH2SCD | |
| SCHEMBL2333285 | 0.71 | GPR119 (0.88) | GPR119KCNH2 | |
| SCHEMBL2521122 | 0.70 | GPR119 (0.85) | GPR119KCNH2SCD | |
| SCHEMBL2337096 | 0.70 | GPR119 (1.00) | GPR119KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2556069-A1 | PYRIMIDINYLPIPERIDINYLOXYPYRIDINONE ANALOGUES AS GPR119 MODULATORS | Bristol-Myers Squibb Company (US) | 2013-02-13 | — | — | EP | disclosed |
| WO-2011127106-A1 | PYRIMIDINYLPIPERIDINYLOXYPYRIDINONE ANALOGUES AS GPR119 MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-10-13 | — | — | WO | disclosed |