Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | YAP1 | P46937 | 16/20 | 0.65 |
| ▸ | CCR1 | P32246 | 1/20 | 0.45 |
| ▸ | ACACB | O00763 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21366293 | 0.94 | YAP1 (0.74) | YAP1ACACB | |
| SCHEMBL21358985 | 0.94 | YAP1 (0.74) | YAP1ACACB | |
| SCHEMBL25756628 | 0.92 | YAP1 (0.67) | YAP1ACACBKMT2A | |
| SCHEMBL22929172 | 0.90 | YAP1 (0.81) | YAP1 | |
| SCHEMBL21366278 | 0.88 | YAP1 (0.81) | YAP1ACACB | |
| SCHEMBL21366480 | 0.88 | YAP1 (0.81) | YAP1ACACB | |
| SCHEMBL25922291 | 0.87 | YAP1 (0.72) | YAP1 | |
| SCHEMBL21366440 | 0.87 | YAP1 (0.69) | YAP1ACACB | |
| SCHEMBL21358889 | 0.87 | YAP1 (0.69) | YAP1ACACB | |
| SCHEMBL21366485 | 0.86 | YAP1 (0.75) | YAP1ACACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11685725-B2 | YAP1 inhibitors that target the interaction of YAP1 with OCT4 | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2023-06-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11685725-B2 | YAP1 inhibitors that target the interaction of YAP1 with OCT4 | YAP1, YES1, MYC | YAP1 1/4885CCR1 4761/4885ACACB 4559/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.