Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 11/20 | 1.00 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.37 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | MITF | O75030 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | XBP1 | P17861 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1096645 | 1.00 | P2RX7 (1.00) | P2RX7DYRK1AMTNR1AMTNR1BNPC1 | |
| SCHEMBL1097005 | 1.00 | P2RX7 (1.00) | P2RX7DYRK1AMTNR1AMTNR1BNPC1 | |
| SCHEMBL1096643 | 1.00 | P2RX7 (1.00) | P2RX7DYRK1AMTNR1AMTNR1BNPC1 | |
| SCHEMBL1096429 | 0.90 | P2RX7 (0.82) | P2RX7MTNR1AMTNR1BTRPV1 | |
| SCHEMBL1097416 | 0.90 | P2RX7 (1.00) | P2RX7DYRK1AMTNR1AMTNR1BNPC1 | |
| SCHEMBL1095761 | 0.90 | P2RX7 (1.00) | P2RX7DYRK1AMTNR1AMTNR1BNPC1 | |
| SCHEMBL1098194 | 0.88 | P2RX7 (0.78) | P2RX7DYRK1ANPC1MITFALDH1A1 | |
| SCHEMBL27863927 | 0.88 | P2RX7 (0.78) | P2RX7DYRK1AMTNR1BNPC1MITF | |
| SCHEMBL1098192 | 0.88 | P2RX7 (0.78) | P2RX7DYRK1ANPC1MITFALDH1A1 | |
| SCHEMBL1097835 | 0.87 | P2RX7 (0.77) | P2RX7MTNR1AMTNR1BALDH1A1MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2382192-A2 | DIHYDROPYRIDONE AMIDES USEFUL AS MEDICAMENTS FOR THE TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISEASES | F. Hoffmann-La Roche AG (CH) | 2011-11-02 | — | — | EP | disclosed |
| WO-2010072647-A2 | DIHYDROPYRIDONE AMIDES AS P2X7 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-07-01 | — | — | WO | disclosed |