Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKDC | P78527 | 9/20 | 0.63 |
| ▸ | ATM | Q13315 | 4/20 | 0.50 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.37 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | AKT1 | P31749 | 1/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15064201 | 0.89 | PRKDC (0.60) | PRKDCATMMAP2K1KIT | |
| SCHEMBL10059179 | 0.88 | PRKDC (0.68) | PRKDCATMGRM4MAP2K1PIK3CD | |
| SCHEMBL256582 | 0.81 | PRKDC (0.74) | PRKDCATMPIK3CDPIK3CAPIK3CB | |
| SCHEMBL15064831 | 0.80 | PRKDC (0.58) | PRKDCATMGRM4 | |
| SCHEMBL10059983 | 0.80 | PRKDC (0.57) | PRKDCATMGRM4PIK3CDPIK3CA | |
| SCHEMBL15064295 | 0.80 | PRKDC (0.73) | PRKDCATMMAP2K1KIT | |
| SCHEMBL15064494 | 0.80 | PRKDC (0.59) | PRKDCATMGRM4PIK3CDPIK3CA | |
| SCHEMBL10059173 | 0.79 | PRKDC (0.82) | PRKDCATMGRM4MAP2K1PIK3CD | |
| SCHEMBL257190 | 0.78 | PRKDC (0.66) | PRKDCATMMAP2K1KIT | |
| SCHEMBL167275 | 0.78 | PRKDC (1.00) | PRKDCATMMAP2K1PIK3CDPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012028233-A1 | IMIDAZO[4,5-C]QUINOLINES AS DNA-PK INHIBITORS | MERCK PATENT GMBH (DE) | 2012-03-08 | — | — | WO | disclosed |