Sugi Predict

Sugi Predict / Compounds / SCHEMBL25759424

SCHEMBL25759424

SCHEMBL25759424

COC(=O)Cc1ncnc(Cl)c1OC

nearest known ligand 0.37

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 4/20 0.37
▸ NPC1 O15118 1/20 0.37
▸ RAB9A P51151 1/20 0.37
▸ SMN1; SMN2 Q16637 2/20 0.36
▸ MAPT P10636 1/20 0.36
▸ HSP90AB1 P08238 1/20 0.35
▸ LMNA P02545 3/20 0.35
▸ KDM4E B2RXH2 2/20 0.35
▸ GAA P10253 2/20 0.35
▸ KMT2A Q03164 1/20 0.35
▸ CYP4F2 P78329 1/20 0.33
▸ CYP4A11 Q02928 1/20 0.33
▸ KMO O15229 1/20 0.33
▸ ENPP1 P22413 1/20 0.33
▸ NR4A1 P22736 1/20 0.32
▸ MTNR1A P48039 1/20 0.32
▸ MTNR1B P49286 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2062770 0.78 ALDH1A1 (0.42) ALDH1A1NPC1RAB9ASMN1; SMN2MAPT
SCHEMBL13064224 0.76 ALDH1A1 (0.38) ALDH1A1NPC1RAB9ASMN1; SMN2MAPT
SCHEMBL13019581 0.75 HSP90AB1 (0.40) ALDH1A1NPC1RAB9ASMN1; SMN2MAPT
SCHEMBL31541799 0.75 TAAR1 (0.34) ALDH1A1NPC1RAB9ASMN1; SMN2MAPT
SCHEMBL21133139 0.75 TAAR1 (0.34) ALDH1A1NPC1RAB9ASMN1; SMN2MAPT
SCHEMBL25288701 0.74 ALDH1A1 (0.35) ALDH1A1RAB9ASMN1; SMN2LMNAKDM4E
SCHEMBL8703270 0.74 ALDH1A1 (0.41) ALDH1A1NPC1RAB9ASMN1; SMN2MAPT
SCHEMBL7199405 0.74 ALDH1A1 (0.39) ALDH1A1SMN1; SMN2MAPTLMNAKMT2A
SCHEMBL9046750 0.74 ALDH1A1 (0.39) ALDH1A1SMN1; SMN2MAPTHSP90AB1LMNA
SCHEMBL31062135 0.73 ALDH1A1 (0.39) ALDH1A1NPC1RAB9ASMN1; SMN2MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250115597-A1 TYK2 INHIBITORS AND COMPOSITIONS AND METHODS THEREOF LYNK PHARMACEUTICALS CO LTD (CN) 2025-04-10 — — US disclosed
US-12129250-B2 TYK2 inhibitors and compositions and methods thereof LYNK PHARMACEUTICALS CO. LTD. (CN) 2024-10-29 — — US disclosed
CN-118401516-A TYK2 inhibitors, compositions and methods thereof 凌科药业(杭州)有限公司 2024-07-26 — — CN disclosed
US-20240124448-A1 TYK2 INHIBITORS AND COMPOSITIONS AND METHODS THEREOF LYNK PHARMACEUTICALS CO. LTD. (CN) 2024-04-18 — — US disclosed
WO-2023109954-A1 TYK2 INHIBITORS AND COMPOSITIONS AND METHODS THEREOF LYNK PHARMACEUTICALS CO. LTD. (CN) 2023-06-22 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240124448-A1 TYK2 INHIBITORS AND COMPOSITIONS AND METHODS THEREOF TYK2, JAK2, JAK1 ALDH1A1 4805/4885NPC1 4269/4885RAB9A 2745/4885
US-20250115597-A1 TYK2 INHIBITORS AND COMPOSITIONS AND METHODS THEREOF TYK2, JAK2, JAK1 ALDH1A1 4805/4885NPC1 4269/4885RAB9A 2745/4885
US-12129250-B2 TYK2 inhibitors and compositions and methods thereof TYK2, JAK2, JAK1 ALDH1A1 4805/4885NPC1 4269/4885RAB9A 2745/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.