Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KRAS | P01116 | 8/20 | 0.66 |
| ▸ | SOS1 | Q07889 | 2/20 | 0.66 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.35 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | RET | P07949 | 2/20 | 0.33 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25763198 | 0.91 | KRAS (0.68) | KRASSOS1ADORA2APIK3CAEGLN2 | |
| SCHEMBL25763175 | 0.91 | KRAS (0.68) | KRASSOS1ADORA2APIK3CAEGLN2 | |
| SCHEMBL25763600 | 0.90 | KRAS (0.60) | KRASSOS1ADORA2APIK3CA | |
| SCHEMBL25763710 | 0.89 | KRAS (0.66) | KRASSOS1ADORA2APIK3CAEGLN2 | |
| SCHEMBL25763741 | 0.89 | KRAS (0.60) | KRASSOS1ADORA2APIK3CAEGLN2 | |
| SCHEMBL25764012 | 0.88 | KRAS (0.83) | KRASSOS1 | |
| SCHEMBL25763659 | 0.88 | KRAS (0.60) | KRASSOS1ADORA2APIK3CAEGLN2 | |
| SCHEMBL25763602 | 0.87 | KRAS (0.63) | KRASSOS1ADORA2APIK3CAEGLN2 | |
| SCHEMBL25763258 | 0.87 | KRAS (0.60) | KRASSOS1ADORA2APIK3CAEGLN2 | |
| SCHEMBL25763759 | 0.85 | KRAS (0.63) | KRASSOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230212164-A1 | ANNULATED 2-AMINO-3-CYANO THIOPHENES AND DERIVATIVES FOR THE TREATMENT OF CANCER | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2023-07-06 | — | — | US | disclosed |
| US-20230212164-A1 | ANNULATED 2-AMINO-3-CYANO THIOPHENES AND DERIVATIVES FOR THE TREATMENT OF CANCER | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2023-07-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230212164-A1 | ANNULATED 2-AMINO-3-CYANO THIOPHENES AND DERIVATIVES FOR THE TREATMENT OF CANCER | RSU1, KRAS, NRAS | KRAS 2/4885SOS1 522/4885ADORA2A 509/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.