Sugi Predict

Sugi Predict / Targets / RSU1

RSU1

Ras suppressor protein 1 · Q15404 · RSU1 on Sugi Atlas →

0 patent compounds predicted against RSU1, 0 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours

Clinical trials — most relevant to RSU1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Treatment With HMG-COA Reductase Inhibitor of Growth and Bone Abnormalities in Children With Noonan Syndrome PHASE3COMPLETED
NEO100 and High-Grade Meningioma PHASE2RECRUITING
Antioxidant Therapy With N-acetylcysteine for Children With Neurofibromatosis Type 1 PHASE2COMPLETED
Antioxidant Therapy With N-acetylcysteine for Learning and Motor Behavior in Children With Neurofibromatosis Type 1 PHASE2COMPLETED
Combination Therapy (Mirdametinib and Sirolimus) for RAS Mutated Relapsed Refractory Multiple Myeloma PHASE1/PHASE2SUSPENDED
BAY 43-9006 (Sorafenib) to Treat Relapsed Non-Small Cell Lung Cancer PHASE2COMPLETED
A Study to Evaluate RAF265, an Oral Drug Administered to Subjects With Locally Advanced or Metastatic Melanoma PHASE1/PHASE2COMPLETED
Study of Sorafenib and Docetaxel in Metastatic Prostate Cancer PHASE2COMPLETED
Phase 2 Study of REOLYSIN® in Combination With Paclitaxel and Carboplatin for Non-Small Cell Lung Cancer With KRAS or EGFR Activation PHASE2COMPLETED
Efficacy and Safety of Cetuximab in Metastatic Penile Carcinoma (PENILANE) PHASE2WITHDRAWN
A Study to Evaluate Efficacy & Safety of Obinutuzumab, Ibrutinib, and Venetoclax in Richter's Syndrome; PHASE2COMPLETED
Use of RAD001 as Monotherapy in the Treatment of Neurofibromatosis 1 Related Internal Plexiform Neurofibromas PHASE2COMPLETED
R115777 to Treat Children With Neurofibromatosis Type 1 and Progressive Plexiform Neurofibromas PHASE2COMPLETED
Temsirolimus and Sorafenib in Advanced Hepatocellular Carcinoma PHASE1COMPLETED
FAK Inhibitor in Patients With Advanced Solid Tumors PHASE1NOT_YET_RECRUITING
A First-in-human Study to Evaluate the Safety, Tolerability and Pharmacokinetics of DS-6051b PHASE1COMPLETED
Expression and Function of the Renin-Angiotensin System in the Esophagus EARLY_PHASE1COMPLETED
Acceptance and Commitment Therapy for Caregivers of Children With a RASopathy: An Internal Pilot Feasibility Study and Follow-up Randomized Controlled Trial nanRECRUITING
Clinical, Genetic, and Epidemiologic Study of Children and Adults With RASopathies nanRECRUITING
Clinical Genetics Branch Eligibility Screening Survey nanNOT_YET_RECRUITING
Long QT Syndrome-Population Genetics and Cardiac Studies nanCOMPLETED
Liquid Biopsies for the Detection of Somatic Mutations in bAVMs nanRECRUITING
Diagnosis of RSTS: Identification of the Acetylation Profiles as Epigenetic Markers for Assessing Causality of CREBBP and EP300 Variants. nanUNKNOWN
RASopathy Biorepository nanRECRUITING
Hematological Anomalies in Children With Rasopathy nanRECRUITING
Solid Tumors in RASopathies nanRECRUITING
Genetics of Hypertension in Blacks nanCOMPLETED
Evaluation of Non-Invasive Assays for the Detection of Urothelial Cancer nanRECRUITING
Prevalence and Characterization of Pain in RASopathies nanUNKNOWN
Pilot Trial of Sirolimus/MEC in High Risk Acute Myelogenous Leukemia (AML) nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a RSU1 binder may also engage these)

ProteinNameSimilarity
Q5E9C0 — 1.000 Q5E9C0 →
Q01730 — 0.998 Q01730 →
Q96LI5 — 0.933 Q96LI5 →
Q8VEG6 — 0.925 Q8VEG6 →
CDC16 Cell division cycle protein 16 homolog 0.923 landscape →
Q27HV0 — 0.923 Q27HV0 →
DHX9 ATP-dependent RNA helicase A 0.922 landscape →
Q8CGY8 — 0.922 Q8CGY8 →
Q9UL63 — 0.921 Q9UL63 →
Q5R874 — 0.921 Q5R874 →
P56558 — 0.921 P56558 →
OGT UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit 0.921 landscape →
Q5RB35 — 0.921 Q5RB35 →
P81436 — 0.920 P81436 →
Q9UKF6 — 0.919 Q9UKF6 →
Q99PV3 — 0.918 Q99PV3 →
O89050 — 0.918 O89050 →
Q96IG2 — 0.918 Q96IG2 →
Q99LC2 — 0.917 Q99LC2 →
Q58DG6 — 0.917 Q58DG6 →
COPS2 COP9 signalosome complex subunit 2 0.916 landscape →
Q8C6G8 — 0.916 Q8C6G8 →
A0A2R8RWN9 — 0.916 A0A2R8RWN9 →
P79101 — 0.915 P79101 →
Q28141 — 0.915 Q28141 →
Q9QXK7 — 0.915 Q9QXK7 →
P61203 — 0.915 P61203 →
Q91854 — 0.915 Q91854 →
Q9CZV8 — 0.915 Q9CZV8 →
Q9JIB4 — 0.914 Q9JIB4 →