Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 11/20 | 0.53 |
| ▸ | IRAK4 | Q9NWZ3 | 5/20 | 0.53 |
| ▸ | IRAK1 | P51617 | 5/20 | 0.53 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.53 |
| ▸ | ABL1 | P00519 | 1/20 | 0.53 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.53 |
| ▸ | FLT4 | P35916 | 1/20 | 0.53 |
| ▸ | KDR | P35968 | 1/20 | 0.53 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.53 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.53 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.53 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.52 |
| ▸ | CDK7 | P50613 | 3/20 | 0.52 |
| ▸ | CCNH | P51946 | 3/20 | 0.52 |
| ▸ | MET | P08581 | 2/20 | 0.48 |
| ▸ | NRAS | P01111 | 6/20 | 0.47 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.43 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19918240 | 0.89 | FLT3 (0.51) | FLT3IRAK4IRAK1PDGFRBCDK7 | |
| SCHEMBL22840809 | 0.84 | FLT3 (0.59) | FLT3IRAK4IRAK1CHEK2ABL1 | |
| SCHEMBL24574418 | 0.84 | IRAK4 (0.49) | FLT3IRAK4IRAK1CHEK2ABL1 | |
| SCHEMBL24574421 | 0.84 | IRAK4 (0.49) | FLT3IRAK4IRAK1CHEK2ABL1 | |
| SCHEMBL31386874 | 0.84 | FLT3 (0.56) | FLT3IRAK4IRAK1CHEK2ABL1 | |
| SCHEMBL24574190 | 0.81 | FLT3 (0.51) | FLT3IRAK4IRAK1PDGFRBCDK7 | |
| SCHEMBL22145707 | 0.81 | FLT3 (0.66) | FLT3IRAK4IRAK1CHEK2ABL1 | |
| SCHEMBL24574511 | 0.81 | FLT3 (0.53) | FLT3IRAK4IRAK1PDGFRBCDK7 | |
| SCHEMBL24574159 | 0.81 | FLT3 (0.51) | FLT3IRAK4IRAK1PDGFRBCDK7 | |
| SCHEMBL24574154 | 0.81 | FLT3 (0.51) | FLT3IRAK4IRAK1PDGFRBCDK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023116888-A1 | FIVE- AND SIX-MEMBERED COMPOUND, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE | 杭州多域生物技术有限公司 | 2023-06-29 | — | — | WO | disclosed |