Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 20/20 | 0.70 |
| ▸ | FLT3 | P36888 | 15/20 | 0.70 |
| ▸ | KIT | P10721 | 14/20 | 0.70 |
| ▸ | CSF1R | P07333 | 9/20 | 0.70 |
| ▸ | FLT4 | P35916 | 9/20 | 0.70 |
| ▸ | FLT1 | P17948 | 8/20 | 0.70 |
| ▸ | LYN | P07948 | 7/20 | 0.70 |
| ▸ | SRC | P12931 | 6/20 | 0.70 |
| ▸ | BLK | P51451 | 6/20 | 0.70 |
| ▸ | PLK4 | O00444 | 4/20 | 0.70 |
| ▸ | AURKA | O14965 | 4/20 | 0.70 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.70 |
| ▸ | MET | P08581 | 4/20 | 0.70 |
| ▸ | PRKACA | P17612 | 4/20 | 0.70 |
| ▸ | RPS6KB1 | P23443 | 4/20 | 0.70 |
| ▸ | CSNK1D | P48730 | 4/20 | 0.70 |
| ▸ | STK3 | Q13188 | 4/20 | 0.70 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.70 |
| ▸ | MARK2 | Q7KZI7 | 4/20 | 0.70 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL422415 | 0.83 | KDR (0.79) | KDRFLT3KITCSF1RFLT4 | |
| Linifanib SCHEMBL93804 | 0.82 | KDR (1.00) | KDRFLT3KITCSF1RFLT4 | |
| Linifanib SCHEMBL29375368 | 0.82 | KDR (1.00) | KDRFLT3KITCSF1RFLT4 | |
| SCHEMBL6073436 | 0.82 | KDR (0.79) | KDRFLT3KITCSF1RFLT4 | |
| Linifanib SCHEMBL1880038 | 0.82 | KDR (0.98) | KDRFLT3KITCSF1RFLT4 | |
| Linifanib SCHEMBL2239943 | 0.80 | KDR (0.94) | KDRFLT3KITCSF1RFLT4 | |
| SCHEMBL25874674 | 0.79 | KDR (0.73) | KDRFLT3KITCSF1RFLT4 | |
| SCHEMBL421458 | 0.77 | KDR (1.00) | KDRFLT3KITCSF1RFLT4 | |
| SCHEMBL25174785 | 0.76 | KDR (1.00) | KDRFLT3KITCSF1RFLT4 | |
| SCHEMBL30501529 | 0.76 | KDR (1.00) | KDRFLT3KITCSF1RFLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230212679-A1 | Method for Predicting Effectiveness of Angiogenesis Inhibitor | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2023-07-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230212679-A1 | Method for Predicting Effectiveness of Angiogenesis Inhibitor | VEGFA, BRAF, FLT4 | KDR 4/4885FLT3 320/4885KIT 157/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.